{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:54:29Z","timestamp":1784753669819,"version":"3.55.0"},"reference-count":90,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515220221"],"award-info":[{"award-number":["2023A1515220221"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","award":["5CD02C72"],"award-info":[{"award-number":["5CD02C72"]}],"id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The inflammatory microenvironment (IME) is closely related to the progression of triple\u2010negative breast cancer (TNBC). As an anti\u2010inflammatory active compound, poor solubility and targeting limit the potential of baicalin (BA) to modulate IME in TNBC. In this study, BA loaded bifunctional albumin nanoparticles (BANP) with long circulation\/acid\u2010sensitive release and active targeting functions are developed to improve the delivery efficiency of BA. BANP have a spherical core\u2013shell structure, with appropriate particle size (79.63 \u00b1 1.91\u00a0nm), zeta potential (\u221233.7 \u00b1 0.82\u00a0mV), and encapsulation efficiency (72.71%), and are released faster in an acidic environment. BANP can enhance the uptake by TNBC cells and \u201cM2\u201d macrophages, prolong circulation time in the blood, and increase accumulation at tumor sites in vivo. It induces cell cycle arrest and early apoptosis in MDA\u2010MB\u2010231 cells and inhibits tumor growth in 4T1 tumor\u2010bearing mice. Additionally, BANP reduce tumor immune infiltration, promote macrophage recruitment and anti\u2010inflammatory M2 polarization, and enhance the phagocytic activity of M2 macrophages. Transcriptome sequencing and cytokine profile analysis reveal that BANP regulate TNBC IME through multitarget mechanisms related to cell cycle, inflammatory response, metabolism, etc. In summary, this study provides a nanodelivery platform with broad application potential and a new strategy for the regulation of IME.<\/jats:p>","DOI":"10.1002\/adhm.202502251","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:01:28Z","timestamp":1755846088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Baicalin\u2010Loaded Bifunctional Albumin Nanoparticles Inhibit Triple\u2010Negative Breast Cancer Growth by Remodeling the Inflammatory Microenvironment"],"prefix":"10.1002","volume":"14","author":[{"given":"Fengjie","family":"Liu","sequence":"first","affiliation":[{"name":"Guangdong Women and Children Hospital  Guangzhou Guangdong 510010 China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment\/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China\/Guangdong Key Lab of Traditional Chinese Medicine Informatization\/International Science and Technology Cooperation Base of Guangdong Province\/School of Pharmacy Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fansu","family":"Meng","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine  Zhongshan Guangdong 528400 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshan","family":"Hong","sequence":"additional","affiliation":[{"name":"Guangdong Women and Children Hospital  Guangzhou Guangdong 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K","family":"Giri","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland (FIMM) HiLIFE\u2010Helsinki Institute of Life Science University of Helsinki Tukholmankatu 8 Helsinki 00290 Finland"},{"name":"Foundation for the Finnish Cancer Institute (FCI)  Tukholmankatu 8 Helsinki 00290 Finland"},{"name":"iCAN Digital Precision Cancer Medicine Flagship University of Helsinki Tukholmankatu 8 Helsinki 00290 Finland"},{"name":"HiLIFE\u2010Helsinki Institute of Life Science University of Helsinki Tukholmankatu 8 Helsinki 00290 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulazim Hussain","family":"Asim","sequence":"additional","affiliation":[{"name":"College of Pharmacy University of Sargodha  Sargodha 40100 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital  Shenzhen 518033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital  Shenzhen 518033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital  Shenzhen 518033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"He","sequence":"additional","affiliation":[{"name":"Guangdong Women and Children Hospital  Guangzhou Guangdong 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaowen","family":"Bu","sequence":"additional","affiliation":[{"name":"Guangdong Women and Children Hospital  Guangzhou Guangdong 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Women and Children Hospital  Guangzhou Guangdong 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangdong Women and Children Hospital  Guangzhou Guangdong 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital  Shenzhen 518033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8532-7816","authenticated-orcid":false,"given":"Yu","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment\/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China\/Guangdong Key Lab of Traditional Chinese Medicine Informatization\/International Science and Technology Cooperation Base of Guangdong Province\/School of Pharmacy Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpet.2023.04.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115545"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12773"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-022-01415-4"},{"key":"e_1_2_10_6_1","first-page":"171","volume":"104","author":"Trayes K. P.","year":"2021","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01341-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01850-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14172"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568009622666211231140623"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042420-093238"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70410"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16605"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.09.038"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010145"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2019.0210"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S316700"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00280-x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00658-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7785890"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-202944"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0273044"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032100"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115414"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-023-01676-7"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.11.002"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50262-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-1427"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136995"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.50928"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.10.015"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-023-01629-0"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001341"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR00656E"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00484-9"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119317"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176427"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110820"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e29361"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.01.002"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28790"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2020.1779318"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910604"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR03353J"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02494-5"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00879"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10101506"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000029328"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.2174\/0118761429263063231204095516"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12645-021-00110-x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6528\/ac197b"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.1c00905"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR06621A"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S467876"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.937"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21545"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.01.001"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180730161721"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSA.S441324"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1634"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-022-02407-5"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1173487"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/733\/1\/012039"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011182"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.galenos.2023.89735"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102636"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47030181"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e14-04-0916"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2014.05.002"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010757"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25204709"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00071"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e14-05-0967"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04278-2"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105444"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115238"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112588"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.808233"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147723"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.11.156"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-017-0142-0"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0241"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10911-024-09556-2"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556-4029.15601"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1226"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105136"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060861"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202502251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:56:46Z","timestamp":1764053806000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202502251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":90,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/adhm.202502251"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202502251","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02251"}}