{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:35:04Z","timestamp":1785216904822,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["ZCLQN25H0403"],"award-info":[{"award-number":["ZCLQN25H0403"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Endometrial injury and subsequent intrauterine adhesions (IUA) challenge reproductive health. Inspired by the blastocyst structure, we developed a core\u2013shell microsphere (HBM) for endometrial regeneration via the dual delivery of bone marrow\u2010derived mesenchymal stem cells (BMSCs) and hyperoside (HYP). Fabricated by microfluidic electrospray, HBM feature a sodium alginate (ALG) shell embedded with Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @MgSiO\n                    <jats:sub>3<\/jats:sub>\n                    magnetic nanoparticle for targeted delivery and a carboxymethyl cellulose (CMC) core encapsulating BMSCs. This design enables spatiotemporal release: shell\u2010HYP modulates early inflammation by polarizing macrophages toward the anti\u2010inflammatory M2 phenotype, whereas BMSCs in the core promote angiogenesis and tissue repair through paracrine signaling. In vitro, HBMs enhanced human umbilical vein endothelial cell proliferation, angiogenesis, and inflammation inhibition. In a rat IUA model, HBM significantly restored endometrial thickness, increases gland numbers, and reduces collagen deposition. \u00a0While also regulating inflammatory microenvironment and enhancing endometrial receptivity. Transcriptomic profiling reveals the activation of immune\u2010modulatory and tissue repair pathways in HBM. This synergistic strategy, combining immunomodulation, stem cell therapy, and magnetic targeting, offers a promising approach for efficient endometrial regeneration and IUA prevention, addressing critical gaps in current clinical.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502293","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:41:53Z","timestamp":1762249313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Blastocyst Structure\u2010Inspired Core\u2013Shell Stem Cell Microspheres with Hyperoside Delivery for Endometrial Regeneration"],"prefix":"10.1002","volume":"15","author":[{"given":"Shun","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Ningbo University  Ningbo Zhejiang Province 315020 China"},{"name":"Institute of Sericulture and Tea Zhejiang Academy of Agricultural Sciences  Hangzhou Zhejiang Province 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqian","family":"Xue","sequence":"additional","affiliation":[{"name":"Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine Zhejiang Shuren University  Hangzhou Zhejiang Province 310015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fubin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Ningbo University  Ningbo Zhejiang Province 315020 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongming","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Ningbo University  Ningbo Zhejiang Province 315020 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Sericulture and Tea Zhejiang Academy of Agricultural Sciences  Hangzhou Zhejiang Province 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Ningbo University  Ningbo Zhejiang Province 315020 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Maternal and Child Health Center of Anhui Medical University The Fifth Affiliated Clinical College of Anhui Medical University  Hefei Anhui Province 230061 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8859-9692","authenticated-orcid":false,"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Sericulture and Tea Zhejiang Academy of Agricultural Sciences  Hangzhou Zhejiang Province 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Ningbo University  Ningbo Zhejiang Province 315020 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2214-z"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00324-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c17645"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba6357"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202490"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202007235"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02620-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.116"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.03.013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.12.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.06.029"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106510"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.04.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.025"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.10.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801455"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ac165a"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c10468"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101580"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900411"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04926"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0718-8"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.4c01075"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0023-5"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c16785"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.733808"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155319"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7478"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.06.025"},{"key":"e_1_2_9_30_1","author":"Yang L.","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.166322"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206004"},{"key":"e_1_2_9_33_1","volume":"499","author":"Huang D. Q.","year":"2024","journal-title":"Chem. Eng. J."},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.11.017"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41427-021-00346-4"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500274"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.09.010"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103317"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308921"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410769"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201680"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2038994"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202502293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202502293","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202502293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:16:23Z","timestamp":1770794183000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202502293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/adhm.202502293"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202502293","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"2025-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02293"}}