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Existing caries treatment protocols are often complex and costly. To simultaneously eradicate caries\u2010associated biofilms and repair demineralized enamel, this study develope a starch\u2010based gum containing calcium carbonate nanoparticles loaded with L\u2010arginine (CaCO\n                    <jats:sub>3<\/jats:sub>\n                    @L\u2010Arg) and glucose oxidase (GOx). The gum can absorb water and swell into a gel. Due to the hydrogen bonding and adhesive properties of gelatinized starch, the starch gel can be freely shaped to fill and adhere to irregular carious cavities. In particular, under the weak acid microenvironment of caries biofilms and the enzymatic action of salivary amylase (Amy), the gel degrades within 3\u20105 hours, releasing GOx and L\u2010Arg. These components trigger a dual enzyme (Amy and GOx) mediated multi\u2010cascade reaction (starch \u2192 glucose \u2192 H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2192 NO) that effectively disrupts biofilms formed by\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    (\n                    <jats:italic>S. mutans<\/jats:italic>\n                    ) and other cariogenic bacteria. At the same time, calcium and phosphate ions released from the gel use the starch as a template to form calcium phosphate in situ, promoting enamel remineralization. This dual\u2010functional system effectively eradicates interdental biofilms and restores enamel, representing a promising strategy for the treatment of early caries.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502346","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T07:30:29Z","timestamp":1756971029000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Starch Gum with a Multi\u2010Cascade Enzymatic Reaction Targeting Dental Caries Biofilm Eradication and Enamel Regeneration"],"prefix":"10.1002","volume":"14","author":[{"given":"Chen","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering Chongqing University  Chongqing 400044 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