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These complications frequently involve excessive reactive oxygen species (ROS) generation and persistent inflammation, pathological features also characteristic of burn wounds and postoperative tumor sites. To address this, an injectable ROS\/pH\u2010responsive hydrogel integrating localized tumor therapy and wound healing is developed. The hydrogel is fabricated via Schiff base crosslinking of a thioketal\u2010based ROS\u2010cleavable linker with aldehyde\u2010functionalized hyaluronic acid, enabling degradation under oxidative and acidic conditions. The hydrogel demonstrates mechanical robustness, excellent biocompatibility, and stimulus\u2010triggered, on\u2010demand drug release. In a breast tumor model, the designed hydrogel facilitates controlled co\u2010delivery of a chemotherapeutic agent 5\u2010fluorouracil (5\u2010FU) and a photosensitizer precursor 5\u2010aminolevulinic acid (ALA), and ensures precise, sustained drug release, achieving synergistic chemo\u2010photodynamic therapy and superior tumor inhibition. Given the pathological similarities between tumor resection wounds and burn injuries, a second\u2010degree burn model is employed to assess the hydrogel's regenerative performance under ROS\u2010rich, inflammation\u2010prone conditions. The hydrogel enables localized antioxidant drug N\u2010acetyl\u2010L\u2010cysteine (NAC) delivery and non\u2010mechanical, on\u2010demand removal. These findings highlight the potential of this multifunctional hydrogel as a minimally invasive, dual\u2010purpose platform for managing cancer\u2010associated tissue injuries and oxidative stress\u2010mediated wound healing.<\/jats:p>","DOI":"10.1002\/adhm.202502349","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T05:36:07Z","timestamp":1755063367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Injectable ROS\/pH\u2010Responsive Hydrogel for Synergistic Chemo\u2010Photodynamic Tumor Therapy and Enhanced Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Danying","family":"Yi","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites Nanjing Tech University  Nanjing 211816 P.R. 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