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Inspired by the negative Poisson's ratio (NPR) effect, a composite ink composed of gelatin methacrylate and polyethylene glycol diacrylate is designed for 3D\u2010printing scaffolds exhibiting NPR properties. Finite element simulation results indicate that the NPR composite scaffold provides uniform stress distribution under NP swelling and can exert a counterforce to inhibit NP protrusion. Additionally, tannic acid is adsorbed on the scaffold's surface, endowing it with antioxidant, anti\u2010inflammatory, and antibacterial properties. In vitro experiments show that the encapsulated anti\u2010inflammatory drug Curcumin and YES\u2010associated protein agonist TT\u201010 delivered by liposomes within ink can be released continuously in the conditions of high reactive oxygen species and inflammatory cytokine overexpression, providing significant protection to NP cells. In vivo tests demonstrate that the NPR scaffold implanted in situ alleviates the IDD process in a rat model by maintaining disc height. This 3D\u2010printed scaffold system with drug delivery and NPR properties represents an innovative and promising strategy for IDD tissue engineering therapy.<\/jats:p>","DOI":"10.1002\/adhm.202502365","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T07:09:32Z","timestamp":1753340972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["3D\u2010Printed Negative Poisson's Ratio Composite Scaffolds with Antibacterial and Microenvironment Remodeling Capacities for Ameliorating Intervertebral Disc Degeneration"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhou","family":"Sha","sequence":"first","affiliation":[{"name":"Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center) School of Medicine Tongji University  Shanghai 200092 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