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Current clinical strategies for PJI treatment face obstacles, including antibiotic resistance, high recurrence rate, and compromised bone repair. To address these challenges, a novel nanozyme\u2010based coordination compound designated as W\u2010GA\u2010Van@Zn is developed. Gallic acid decorated tungsten nanozyme (W\u2010GA) with dual photothermal and reactive oxygen species (ROS) scavenging ability is chosen as the core of W\u2010GA\u2010Van@Zn, and vancomycin as a bacterial targeting agent is decorated on W\u2010GA surface using amide reaction. After that, zinc ions are introduced and formed a metal\u2010phenolic coordination compound across by the polyphenolic groups on the nanozyme surface. W\u2010GA\u2010Van@Zn could achieve bacterial targeting ability through specific binding to D\u2010Ala\u2010D\u2010Ala moieties on the bacterial surface, and realize synergistic PJI treatment combining mild photothermal therapy (PTT) and antibiotic therapy. Meanwhile, the nanozyme could simultaneously scavenge PTT\u2010generated ROS, overcoming the side effect during PTT treatment. Besides, PTT\u2010antibiotic combination therapy reduced antibiotic dosage and provided excellent bactericidal efficacy at low antibiotic concentrations. During the bone repair stage post\u2010PJI treatment, the nanozyme sustained ROS scavenging to reduce inflammatory microenvironment, together with zinc ions for synergistic bone repairment.<\/jats:p>","DOI":"10.1002\/adhm.202502379","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:06:48Z","timestamp":1757570808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Novel Nanozyme\u2010based Coordination Compound for Synergistic Periprosthetic Joint Infection Treatment and Bone Repair"],"prefix":"10.1002","volume":"15","author":[{"given":"Siyu","family":"Yang","sequence":"first","affiliation":[{"name":"Hebei Key Laboratory of Biomaterials and Smart Theranostics School of Health Sciences and Biomedical Engineering Hebei University of Technology  Tianjin 300131 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