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To address these limitations, we engineered Gd@CAT\n                    <jats:sup>Ce6<\/jats:sup>\n                    (GCC) via catalase (CAT)\u2010mediated biomimetic synthesis, where CAT serves as a structural template for the green synthesis of gadolinium\u2010based nanoparticles, an enzymatic oxygenator through H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    decomposition, and a hydrophobic host for photosensitizer chlorin e6 (Ce6) loading. GCC leverages CAT's enzymatic activity to decompose tumor\u2010overexpressed H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into oxygen, effectively mitigating hypoxia while amplifying Ce6\u2010mediated reactive oxygen species (ROS) generation under laser irradiation. In vitro studies confirmed a uniform nanostructure (approximately 10\u00a0nm), high longitudinal relaxivity (r\n                    <jats:sub>1<\/jats:sub>\n                    = 10.9 m\n                    <jats:sc>m<\/jats:sc>\n                    <jats:sup>\u22121<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), and potent ROS production. In vivo magnetic resonance imaging (MRI) demonstrated significant tumor accumulation via the enhanced permeability and retention (EPR) effect, extending the imaging window to 1\u20132 h for precise therapy guidance. Notably, GCC combined with laser irradiation suppressed 4T1 tumor growth by 87.84% in mice, outperforming controls, while exhibiting good biocompatibility in blood and organ toxicity assays. This work presents an enzyme\u2010based theranostic strategy that synergizes real\u2010time imaging with self\u2010oxygenating PDT, offering a promising solution to overcome hypoxia\u2010driven therapeutic resistance.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502430","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:25:56Z","timestamp":1773390356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biomimetic Catalase\u2010Templated Nanoprobes for MRI\u2010Guided Oxygen\u2010Supplemented Photodynamic Therapy in Breast Cancer"],"prefix":"10.1002","volume":"15","author":[{"given":"Wen","family":"Gu","sequence":"first","affiliation":[{"name":"School of Health Science and Engineering University of Shanghai for Science and Technology  Shanghai China"},{"name":"Department of Radiology Changzheng Hospital Second Military Medical University  Shanghai 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