{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:38:06Z","timestamp":1790253486335,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2222013"],"award-info":[{"award-number":["T2222013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Glaucoma stands as a leading cause of irreversible blindness worldwide. Glaucoma filtration surgery (GFS) is the main surgical approach for its treatment. However, postoperative inflammation or immune responses can stimulate excessive scar formation, compromising surgical outcomes and potentially leading to complications such as uncontrolled intraocular pressure (IOP). This study aimed to develop a suturable polyzwitterionic hydrogel by combining 2\u2010((2\u2010hydroxy\u20103\u2010(methacryloyloxy) propyl) dimethyl ammonio) acetate (CBOH), a zwitterionic monomer containing hydroxyl groups, with 2\u2010hydroxyethyl methacrylate (HEMA) to prevent GFS\u2010induced scar formation. The introduction of the CBOH component imparts excellent antifouling properties and a relatively low modulus, giving it mechanical characteristics similar to native ocular tissue. This facilitates the prevention of scar tissue formation following GFS and reduces foreign body sensation caused by long\u2010term implant materials. In an animal model of GFS, P(HEMA\u2010CBOH) hydrogel maintained filtration bleb survival and lowered\u00a0IOP for up to 4 weeks postoperatively. Furturemore, it reduced collagen deposition and \u03b1\u2010SMA expression within conjunctival and scleral tissue, demonstrating their efficacy in inhibiting scar formation and improving GFS outcomes. Overall, as a suturable, drug\u2010free polyzwitterionic hydrogel, P(HEMA\u2010CBOH) holds significant potential for clinical applications in GFS, largely due to its inherent antifouling properties.<\/jats:p>","DOI":"10.1002\/adhm.202502458","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:31:08Z","timestamp":1756467068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Suturable and Drug\u2010Free Polyzwitterionic Hydrogel for Alleviating Scar Formation After Glaucoma Filtration Surgery"],"prefix":"10.1002","volume":"15","author":[{"given":"Huijie","family":"Hao","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin 300384 China"},{"name":"School of Materials Science and 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