{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:51:41Z","timestamp":1786798301291,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62574177"],"award-info":[{"award-number":["62574177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402863"],"award-info":[{"award-number":["82402863"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Functionalized hydrogel microspheres hold great promise in tissue regeneration, yet their clinical translation is often hindered by high production costs, complex fabrication processes, and reliance on external bioactive additives. To overcome these challenges, multifunctional gelatin\u2010tea polyphenol (GTP) microgels using a simplified, cost\u2010effective, microfluidics\u2010inspired platform are reported, which is composed of an injection unit, a reciprocating apparatus, and a collection substrate. Using a microinjection pump, uncrosslinked microspheres with precisely controlled diameters (125\u2013570\u00a0\u00b5m) are generated, followed by in situ crosslinking to form GTP microgels, which exhibit excellent stability (&gt;28 days) and rapid water absorption (&gt;300% within 1\u00a0min). These GTP microgels display outstanding hemostatic performance, potent antioxidant activity, and excellent photothermal effects. In mouse burn models, GTP microgels combined with photothermal stimulation accelerate wound healing by reducing inflammation and promoting angiogenesis. By integrating intrinsic therapeutic functions, such as hemostasis, anti\u2010inflammation, and pro\u2010angiogenesis, with a simplified fabrication process, GTP microgels offer a clinically viable approach for advanced wound management.<\/jats:p>","DOI":"10.1002\/adhm.202502477","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:48:21Z","timestamp":1762433301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microfluidics\u2010Inspired Microgels with Intrinsic Bioactivity for Advanced Burn Wound Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Zongguang","family":"Liu","sequence":"first","affiliation":[{"name":"Microelectronics Industry Research Institute College of Physics Science and Technology Yangzhou University  Yangzhou 225009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Microelectronics Industry Research Institute College of Physics Science and Technology Yangzhou University  Yangzhou 225009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid &amp; Cell Fate Regulation School of Basic Medical Sciences &amp; School of Public Health Faculty of Medicine Yangzhou University  Yangzhou 225009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control School of Traditional Chinese Medicine Faculty of Medicine Yangzhou University  Yangzhou 225009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Wu","sequence":"additional","affiliation":[{"name":"Microelectronics Industry Research Institute College of Physics Science and Technology Yangzhou University  Yangzhou 225009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"An","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing 210008 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0646-5234","authenticated-orcid":false,"given":"Jianmei","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control School of Traditional Chinese Medicine Faculty of Medicine Yangzhou University  Yangzhou 225009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00715-1"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202404461"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.08.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401539"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0148-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1239183"},{"key":"e_1_2_9_7_1","first-page":"205","volume":"5","author":"Zhang P.","year":"2024","journal-title":"Biomater. Transl."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202301092"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202306598"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.110478"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.06.037"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202403781"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315590"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207211"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ac57a5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210036"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2022.07.004"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.09.010"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.124715"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.07.007"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202203306"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131837"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0591"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA02566D"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2017.1381111"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2025.111483"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.126505"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202306598"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c18284"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.12.004"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC02888F"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.133382"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.3c01413"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201604894"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131772"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c02030"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11053"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20220025"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20220032"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1389327"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202104229"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.11.040"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.02.032"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b07598"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.3c01413"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c18664"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101075"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202502477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202502477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202502477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:16:35Z","timestamp":1770794195000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202502477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/adhm.202502477"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202502477","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"assertion":[{"value":"2025-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02477"}}