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Some therapeutics like RNAs and anti\u2010oxidation drugs have been developed to regulate the functions of mitochondria, but are hardly delivered into brain effectively due to the blood\u2010brain barrier (BBB). H\n                    <jats:sub>2<\/jats:sub>\n                    has recently been verified able to overcome the BBB efficiently and has a unique wide\u2010spectrum anti\u2010oxidation\/anti\u2010inflammation effect, but sustainable, high\u2010amount, and safe delivery of H\n                    <jats:sub>2<\/jats:sub>\n                    into brain is still challenging currently. Herein, we develop an innovative H\n                    <jats:sub>2<\/jats:sub>\n                    administration method of intraperitoneal injection of magnesium hydride microparticles (MgH\n                    <jats:sub>2<\/jats:sub>\n                    ) with a high payload of hydrogen and a sustained hydrolytic H\n                    <jats:sub>2<\/jats:sub>\n                    production behavior, achieving persistent and high\u2010dose supply of H\n                    <jats:sub>2<\/jats:sub>\n                    into the blood system as well as in the brain. In addition, we establish a novel CIRI rabbit model induced by transcarotid artery revascularization (TCAR), which leads to oxidative stress and subsequent ferroptosis in the brain's hippocampus. In this CIRI model, MgH\n                    <jats:sub>2<\/jats:sub>\n                    treatment eliminates intracellular ROS, inhibits neuronal ferroptosis, and recovers mitochondrial dysfunction by stabilizing mitochondrial membrane potential, regulating mitobiogenesis, promoting neuronal energy metabolism, and activating the anti\u2010oxidative pathway. All these findings demonstrate that MgH\n                    <jats:sub>2<\/jats:sub>\n                    treatment provides a potential strategy for CIRI.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502482","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T07:42:39Z","timestamp":1766994159000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Constructing Mg\u2010Based Hydrogen Container for Mitochondrial Dysfunction and Neuronal Ferroptosis in TCAR\u2010Induced Cerebral Ischemia\/Reperfusion Injury"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-1622","authenticated-orcid":false,"given":"Weijian","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery Huashan Hospital of Fudan University  Shanghai P. R. 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