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A one\u2010step coordinated synthesis of\n                    <jats:bold>BODIPY<\/jats:bold>\n                    \u2010integrated photodynamic nanozymes (\n                    <jats:bold>FZBNPs<\/jats:bold>\n                    ) that facilitate an orthogonal catalytic cascade for radiotherapy potentiation is presented. The engineered\n                    <jats:bold>FZBNPs<\/jats:bold>\n                    simultaneously alleviate tumor hypoxia through catalase\u2010mimetic oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ) generation and amplify reactive oxygen species (ROS) production via peroxidase\u2010like activity, synergizing with\n                    <jats:bold>BODIPY<\/jats:bold>\n                    \u2010mediated singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) generation under 660\u00a0nm light irradiation. Crucially,\n                    <jats:bold>FZBNPs<\/jats:bold>\n                    deplete intracellular glutathione (GSH) and trigger ferroptosis through lipid peroxidation (LPO) accumulation, directly countering radiotherapy resistance. In vivo validation revealed that the\n                    <jats:bold>FZBNPs<\/jats:bold>\n                    \u2010driven multi\u2010enzymatic cascades achieved near\u2010complete tumor ablation in breast cancer models during radiotherapy. This work establishes a therapeutic paradigm that integrates oxygen modulation, ROS amplification, redox homeostasis disruption, and ferroptosis induction, offering a conceptual basis for the application of enzyme\u2010mimetic nanoplatforms in precision radiation oncology.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502530","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T04:58:51Z","timestamp":1757307531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multi\u2010Enzymatic Cascade Catalysis in Photodynamic Nanozymes for Augmenting Radiotherapy of Breast Cancer"],"prefix":"10.1002","volume":"14","author":[{"given":"Guoqing","family":"Cui","sequence":"first","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Jiangsu Province Engineering Research 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