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Through intermolecular \u03c0\u2013\u03c0 stacking, polar interactions, and hydrophobic effects, PP\u2010SiPc self\u2010assembled into J\u2010aggregated nanoshuttles (N\u2010PP\u2010SiPc)\u00a0that exhibit enhanced UV\/Vis absorption, intensified fluorescence, and superior photostability compared to the free form of PP\u2010SiPc. N\u2010PP\u2010SiPc demonstrates high specificity for lipid droplets (LDs), enabling dynamic tracking and discrimination between lysosomal and non\u2010lysosomal LDs\u2014a critical capability for identifying drug\u2010induced lipidosis associated with abnormal accumulation of non\u2010lysosomal LDs. Furthermore, N\u2010PP\u2010SiPc exhibits rapid cellular internalization, improved targeting of LDs, and enhanced light\u2010triggered reactive oxygen species (ROS) generation. These properties collectively contributed to potent PDT efficacy against both cancer cells and drug\u2010resistant strains, underscoring its potential as a theranostic platform capable of overcoming resistance mechanisms. This work establishes a blueprint for developing transporter\u2010modulated theranostic nanomaterials offering organelle\u2010level diagnostic precision.<\/jats:p>","DOI":"10.1002\/adhm.202502542","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T11:39:34Z","timestamp":1759491574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rational Design of Probenecid\u2010Functionalized Silicon Phthalocyanine J\u2010Aggregated Nanoshuttles for Lipid Droplet\u2010Targeted Drug\u2010Resistant Theranostics"],"prefix":"10.1002","volume":"15","author":[{"given":"Yating","family":"Shen","sequence":"first","affiliation":[{"name":"College of Chemistry &amp; Material, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Province Key Laboratory of Polymer Materials Fujian Normal University  Fuzhou 350117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; 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