{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:33:36Z","timestamp":1790440416504,"version":"4.1.0"},"reference-count":91,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Phosphate and phosphate invert glasses contain various elements, with a wide range of compositions. Recently, our group reported orthosilicophosphate glasses (SPGs) and the glass network structure composed of orthophosphates and orthosilicates crosslinked by cations. ZnO is an intermediate oxide that improves the chemical durability of glass. Additionally, Zn\n                    <jats:sup>2+<\/jats:sup>\n                    ions exhibit antibacterial activity and stimulate bone formation. In this work, ZnO\u2010containing SPGs are prepared for biomedical applications. The glasses are mainly composed of PO\n                    <jats:sub>4<\/jats:sub>\n                    , SiO\n                    <jats:sub>4<\/jats:sub>\n                    , MgO\n                    <jats:sub>4<\/jats:sub>\n                    , and ZnO\n                    <jats:sub>4<\/jats:sub>\n                    orthotetrahedral structures. The ZnO\u2010containing SPGs exhibit excellent antibacterial activity, with bacterial counts &gt; 5 orders of magnitude lower than that of the control. Meanwhile, ZnO\u2010containing SPGs have mild inhibitory effects on cell proliferation by Zn\n                    <jats:sup>2+<\/jats:sup>\n                    ions; however, they exhibit significant upregulation of osteogenic markers compared with the control owing to the release of inorganic ions from the glasses. The ZnO\u2010containing SPGs prepared in this work exhibit bifunctional properties suitable for biomedical applications. They serve as bioadaptive materials capable of controlling gene expression by releasing therapeutic ions.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502546","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T09:27:14Z","timestamp":1757150834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preparation of Bifunctional Orthosilicophosphate MgO\u2010CaO\u2010ZnO\u2010P\n                    <sub>2<\/sub>\n                    O\n                    <sub>5<\/sub>\n                    \u2010SiO\n                    <sub>2<\/sub>\n                    Glasses: In Vitro Evaluation of Antibacterial Activity and Osteoblast Gene Expression Behavior"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-9573","authenticated-orcid":false,"given":"Sungho","family":"Lee","sequence":"first","affiliation":[{"name":"National Institute of Advanced Industrial Science and Technology (AIST)  Nagoya 463\u20138560 Japan"},{"name":"Division of Materials and Manufacturing Science Graduate School of Engineering The University of Osaka  Osaka 565\u20130871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Asano","sequence":"additional","affiliation":[{"name":"National Institute of Advanced Industrial Science and Technology (AIST)  Nagoya 463\u20138560 Japan"},{"name":"Department of Applied Chemistry College of Engineering Chubu University  Kasugai 487\u20138501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-5552","authenticated-orcid":false,"given":"Makoto","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry College of Engineering Chubu University  Kasugai 487\u20138501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8052-1698","authenticated-orcid":false,"given":"Takayoshi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Division of Materials and Manufacturing Science Graduate School of Engineering The University of Osaka  Osaka 565\u20130871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8745-8932","authenticated-orcid":false,"given":"Toshihiro","family":"Kasuga","sequence":"additional","affiliation":[{"name":"Division of Advanced Ceramics, Graduate School of Engineering Nagoya Institute of Technology  Nagoya 466\u20138555 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"5","volume-title":"Fundamentals of Inorganic Glasses","author":"Varshneya A. 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