{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:09:28Z","timestamp":1792465768087,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bacterial infections pose a significant challenge to global health, as conventional treatments frequently cause side effects and resistance. Phototherapy, encompassing photothermal therapy (PTT) and photodynamic therapy (PDT), emerges as a viable alternative, eradicating bacteria through heat and reactive oxygen species (ROS). However, excessive heat and ROS can exacerbate local inflammation and comlicate healing. To address these challenges, we developed a novel chitosan\u2010based nanoparticle (NPs) encapsulating S\u2010nitrosoglutathione (GSNO) and indocyanine green (ICG), termed as GSNO\/ICG@NPs. This biocompatible nanosystem integrates the triple synergistic effects of nitric oxide (NO) release, PTT, and PDT. The stable and uniformly shaped GSNO\/ICG@NPs were synthesized via a charge\u2010driven self\u2010assembly method with efficient loading of GSNO and ICG. Upon irradiation with an 808\u00a0nm near\u2010infrared (NIR) laser, GSNO\/ICG@NPs rapidly generate heat and\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , effectively eliminating bacteria. Simultaneously, the photothermal effect releases NO from GSNO, modulates inflammation, promotes neovascularization, and supports tissue repair. In vitro and in vivo studies demonstrated that GSNO\/ICG@NPs significantly enhance antibacterial activity, reduce inflammation, and promote angiogenesis. It effectively eradicated biofilms and accelerated wound healing in a\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    \u2010infected mouse skin model. These findings highlight GSNO\/ICG@NPs as a promising alternative to antibiotics for treating infected wounds via synergistic therapy involving balanced NO release, PTT, and PDT.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502584","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T07:58:20Z","timestamp":1759305500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nitric Oxide\u2010Enhanced Chitosan\u2010Based Nanoparticles for Dual\u2010Mode Photothermal and Photodynamic Therapy in Infected Wounds"],"prefix":"10.1002","volume":"15","author":[{"given":"Yueting","family":"Li","sequence":"first","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University The First Affiliated Hospital of Lishui University Lishui People's Hospital  Lishui Zhejiang 323000 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323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0057-267X","authenticated-orcid":false,"given":"Shuanghu","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University The First Affiliated Hospital of Lishui University Lishui People's Hospital  Lishui Zhejiang 323000 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