{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:39:45Z","timestamp":1792438785634,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12072096"],"award-info":[{"award-number":["12072096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["HIT.DZJJ.2024024"],"award-info":[{"award-number":["HIT.DZJJ.2024024"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Plantar wounds, particularly diabetic foot ulcers (DFUs), impose significant burdens on patients' quality of life and healthcare systems. Personalized wound management demands real\u2010time monitoring of biomechanical parameters and effective therapeutic interventions to prevent exacerbations. Here, a dual\u2010layer flexible liquid metal fiber (LMF) capable of simultaneous plantar pressure sensing and electrical stimulation for accelerated wound healing is presented. The fiber features an LM\u2010filled core that transduces mechanical deformation into resistance changes for pressure mapping, while its LM\u2010copper (LM\u2010Cu) alloy coating delivers programmable electrical stimulation to mimic endogenous bioelectric fields. In a murine infected wound model, the device significantly enhances wound closure by promoting epithelial migration, modulating inflammation, and stimulating angiogenesis. Integrated with Bluetooth\u2010enabled wireless transmission and a smartphone interface, the system provides real\u2010time plantar pressure visualization, threshold\u2010based alerts, and on\u2010demand electrotherapy. This multifunctional fiber offers a compact, wearable solution for holistic diabetic foot care, bridging the gap between diagnostic monitoring and therapeutic intervention.<\/jats:p>","DOI":"10.1002\/adhm.202502681","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:36:13Z","timestamp":1756899373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dual\u2010Layer Flexible Liquid Metal Fiber for Plantar Pressure Monitoring and Synchronous Wound Electrotherapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Zhenyou","family":"Ge","sequence":"first","affiliation":[{"name":"State Key Laboratory of Robotics and System Harbin Institute of Technology  Harbin 150001 P. R. China"},{"name":"School of Mechatronics Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tao","sequence":"additional","affiliation":[{"name":"School of Mechatronics Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Mechatronics Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhou","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshang","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Robotics and System Harbin Institute of Technology  Harbin 150001 P. R. China"},{"name":"School of Mechatronics Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Electronics and Control Engineering Chang'an University  Xi'an 710064 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Robotics and System Harbin Institute of Technology  Harbin 150001 P. R. China"},{"name":"School of Mechatronics Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhe","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Robotics and System Harbin Institute of Technology  Harbin 150001 P. R. China"},{"name":"School of Mechatronics Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Mechatronics Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Robotics and System Harbin Institute of Technology  Harbin 150001 P. R. China"},{"name":"School of Mechatronics Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tu","sequence":"additional","affiliation":[{"name":"Hangzhou Huier Hearing Instrument &amp; Technique Co.,Ltd  Hangzhou 310000 P. R. China"},{"name":"Hangzhou Ren\u2010Ai Hearing Rehabilitation Research Center  Hangzhou 310000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Shi","sequence":"additional","affiliation":[{"name":"Hangzhou Huier Hearing Instrument &amp; Technique Co.,Ltd  Hangzhou 310000 P. R. China"},{"name":"Hangzhou Ren\u2010Ai Hearing Rehabilitation Research Center  Hangzhou 310000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Fourth Affiliated Hospital of Harbin Medical University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbin","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Mechatronics Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Robotics and System Harbin Institute of Technology  Harbin 150001 P. R. China"},{"name":"School of Mechatronics Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0477-4"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00543.x"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan4950"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abc4327"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade4687"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf7388"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202111022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114528"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25324-w"},{"key":"e_1_2_9_5_3","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-024-00390-z"},{"key":"e_1_2_9_5_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c02919"},{"key":"e_1_2_9_5_5","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu1598"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41378-020-0171-1"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202100566"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100852"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.212.2000190"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl8379"},{"key":"e_1_2_9_10_1","author":"Jiang Y.","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0442"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04925"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700465"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS00413B"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-019-02143-0"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado7538"},{"key":"e_1_2_9_14_1","author":"Wu H.","year":"2024","journal-title":"Nat. Electron."},{"key":"e_1_2_9_15_1","author":"Liu S.","year":"2023","journal-title":"Adv. Fiber Mater."},{"key":"e_1_2_9_15_2","author":"Zhou X.","year":"2023","journal-title":"Adv. Mater."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29859-4"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-020-00902-3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00802-0"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg4041"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39928-x"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202308120"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202205196"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b10937"},{"key":"e_1_2_9_19_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b19823"},{"key":"e_1_2_9_19_4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1712195114"},{"key":"e_1_2_9_20_1","author":"Yang S. B.","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115414"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39928-x"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00859-5"},{"key":"e_1_2_9_21_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315086"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.200701216"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201203589"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307546"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b08067"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104298"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.34133\/2020\/7286735"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3028"},{"key":"e_1_2_9_25_3","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1159"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202502681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T14:42:15Z","timestamp":1768056135000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202502681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,3]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/adhm.202502681"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202502681","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,3]]},"assertion":[{"value":"2025-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02681"}}