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Current treatments often fail to eliminate persistent inflammation and regenerate damaged tissue. Here, an ROS\u2010responsive multifunctional micelle system (HA\u2010PMs@Ce) constructed by self\u2010assembly of the block copolymer polyethylene glycol\u2013polylysine\/phenylboronic acid (PLLA\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010PLys\/PBA) and tannic acid (TA) is proposed, encapsulating cerium oxide (CeOx) nanozyme and coated with hyaluronic acid (HA). The catechol groups in TA form ROS\u2010sensitive borate ester bonds with PBA, while electrostatic interactions between anionic HA and cationic PLys stabilize the micelle structure. In the oxidative microenvironment of periodontitis, excess ROS cleaves HA\u2010PMs@Ce, triggering the release of CeOx and TA on demand. CeOx mimics superoxide dismutase activity to scavenge ROS and alleviate oxidative stress, whereas TA provides antibacterial effects to prevent local infection. Furthermore, the micelle system reprograms M1 macrophages into the M2 phenotype, reduces pro\u2010inflammatory cytokines, and upregulates osteogenic gene expression, thereby attenuating inflammation and promoting tissue regeneration. Notably, HA\u2010PMs@Ce restores mitochondrial function and mitigates ROS\u2010induced damage. Overall, this nanozyme\u2010based micelle platform offers a promising strategy for the treatment of periodontitis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502690","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T10:45:29Z","timestamp":1755773129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Complexed Micelles System Based on Ceria Oxide Nanozyme for Bone Remodeling and ROS Scavenging in Periodontitis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7390-8389","authenticated-orcid":false,"given":"Yue","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University  Shanghai 200011 China"},{"name":"National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Engineering Research Center of Advanced Dental Technology and Materials  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University  Shanghai 200011 China"},{"name":"National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Engineering Research Center of Advanced Dental Technology and Materials  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Shanghai Ninth People's Hospital 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200011 China"},{"name":"Shanghai Stomatological Hospital Shanghai Key Laboratory of Stomatology Shanghai Engineering Research Center of Advanced Dental Technology and Materials Fudan University  Shanghai 201102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University  Shanghai 200011 China"},{"name":"National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Engineering Research Center of Advanced Dental Technology and Materials  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinquan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Shanghai 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