{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:31:57Z","timestamp":1789543917473,"version":"build-2803163510"},"reference-count":196,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171032"],"award-info":[{"award-number":["82171032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501251"],"award-info":[{"award-number":["82501251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Retinal damage remains a leading cause of irreversible vision loss, with conventional surgical and pharmacological approaches limited by suboptimal efficacy and safety concerns. Mesenchymal stem cell\u2010derived extracellular vesicles (MSC\u2010EVs) demonstrate promise for retinal repair through their low immunogenicity, anti\u2010inflammatory, antioxidant, and neuroprotective properties. These nanovesicles deliver functional proteins and miRNAs that enhance neuronal survival, suppress pathological angiogenesis, and attenuate inflammatory cascades, demonstrating efficacy in models of retinal injury. However, rapid systemic clearance and frequent dosing requirements hinder clinical translation. Hydrogel\u2010based delivery systems address these challenges by improving intraocular retention and bioavailability via biocompatibility, controlled release, and barrier protection. This review critically analyzes current retinal treatments, discusses the mechanisms and translational challenges of MSC\u2010EVs, and evaluates the design principles of hydrogel biomaterials. It also synthesizes progress in hydrogel\u2010EV combination strategies for ocular diseases, highlighting their synergistic therapeutic effects while addressing scalability and biosafety issues. The innovative integration of biomaterial and EV therapeutics advances targeted approaches for retinal regeneration.<\/jats:p>","DOI":"10.1002\/adhm.202502691","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:40:37Z","timestamp":1769496037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Harnessing Mesenchymal Stem Cell\u2010Derived EVs\u2010Loaded Hydrogels: Therapeutic Mechanisms and Applications in Retinal Injury Repair"],"prefix":"10.1002","volume":"15","author":[{"given":"Yumeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Third People's Hospital of Dalian Dalian Eye Hospital  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Qi","sequence":"additional","affiliation":[{"name":"Third People's Hospital of Dalian Dalian Eye Hospital  Dalian China"},{"name":"Ophthalmology and Transformational Innovation Research Center Faculty of Medicine of Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludan","family":"Sun","sequence":"additional","affiliation":[{"name":"Third People's Hospital of Dalian Dalian Eye Hospital  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Third People's Hospital of Dalian Dalian Eye Hospital  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Yan","sequence":"additional","affiliation":[{"name":"Third People's Hospital of Dalian Dalian Eye Hospital  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Dong","sequence":"additional","affiliation":[{"name":"Third People's Hospital of Dalian Dalian Eye Hospital  Dalian China"},{"name":"Ophthalmology and Transformational Innovation Research Center Faculty of Medicine of Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanan","family":"Wang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bio\u2010Intelligent Manufacturing Dalian Key Laboratory of Artificial Organ and Regenerative Medicine School of Bioengineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Third People's Hospital of Dalian Dalian Eye Hospital  Dalian China"},{"name":"Ophthalmology and Transformational Innovation Research Center Faculty of Medicine of Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-3094","authenticated-orcid":false,"given":"Chuanfeng","family":"An","sequence":"additional","affiliation":[{"name":"Third People's Hospital of Dalian Dalian Eye Hospital  Dalian China"},{"name":"Ophthalmology and Transformational Innovation Research Center Faculty of Medicine of Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010024\u201000501\u20105"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16330"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113554"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8883616"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.02.040"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201002955\u20103"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2023.09.008"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042124"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17070923"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2305947121"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15069372"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41427\u2010022\u201000419\u2010y"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015\u2010020\u201010090\u2010x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.04.011"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479\u20105876\u20109\u201029"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18\u201025310"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00377"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051254"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202300379"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c00525"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124287"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3791\/65003"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.01.002"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804591"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010025\u201001120\u2010w"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081406"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051484"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061816"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010018\u20104692\u20101"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i7.939"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c03231"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.13389\/j.cnki.rao.2024.0001"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001948"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47865"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/diabetology3010011"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.1.227.227"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091342"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1100254"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021024"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy338"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2024.1354569"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1184060"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366\u20106999.20131956"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2023.19"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.103222"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010021\u201002236\u20106"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/encyclopedia2040124"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792\u2010023\u201002767\u20102"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11133627"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/546786"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100858"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2022.02.026"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)02609\u20105"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bau047"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.245465"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2023.101193"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116424"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.1126"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2024.110129"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22169050"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112792"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15041167"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.123066"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015\u2010020\u201010040\u20107"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.16\u20100428"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792\u2010022\u201002530\u2010z"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2022.102181"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.06.006"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117019"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15071992"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022126\u2010y"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201604024"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010020\u201001702\u2010x"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.04.028"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010020\u201002064\u20100"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.11.005"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010020\u201002130\u20107"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1319"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2021.11.06"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.2.6"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010018\u20101154\u20101"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2019.01.006"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11233720"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12860\u2010023\u201000467\u20104"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S475234"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2021.12.04"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201003079\u2010y"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107010"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR\u2010D\u201023\u201001642"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119232"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41434\u2010021\u201000310\u20105"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540\u2010018\u20102465\u20100"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14443"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2023.112240"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886\u2010017\u20100572\u20106"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8546423"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.79784"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010024\u201001460\u2010x"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.01.016"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201001944\u2010w"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20180079"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010024\u201001753\u20108"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010022\u201003100\u2010x"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010024\u201001920\u20103"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010020\u20101549\u20106"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30213"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.04.008"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201004559\u2010y"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34562"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18\u201025617"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2024.109919"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201094365\u20104"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb9010013"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11837\u2010017\u20102412\u20109"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.07.053"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.110"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010019\u20106318\u20107"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12112702"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.05.096"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201703086"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2003.02.002"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.08.019"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.est.2023.109508"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c00878"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2017.07.002"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00688"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0ra01790f"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA09632A"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570\u2010019\u201002797\u2010z"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2016.12.023"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112327"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.201800234"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2017.02.025"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202102818"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883911515597704"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2012.04.022"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.55836"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10854\u2010021\u201006939\u20107"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.3c02279"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1080\/02726351.2022.2134066"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2011.06.003"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7cc02435e"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm005517h"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra21021f"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10924\u2010021\u201002184\u20105"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2017.12.004"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.3c00824"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.4c00266"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/pi.6266"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201600284"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmps.2018.03.018"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427\u2010019\u20101710\u20108"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.04.003"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105586"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.02.026"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1545636"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.04.007"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130843"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf7207"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.130634"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0469"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2021.100195"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c00423"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01368"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010023\u201000551\u20103"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2004.05.004"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24030603"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.103266"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c01636"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113608"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200060"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1nj01228b"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.03.181"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.3c01253"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.39566"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b10126"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b10491"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaf059"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17020215"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.09.034"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.152463"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c05512"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.03.001"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.07.028"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.158"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108541"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308635"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.643402"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c17626"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.154509"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1202704"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23880"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102541"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102052"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2023.134396"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202502691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202502691","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202502691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:27:45Z","timestamp":1781501265000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202502691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":196,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/adhm.202502691"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202502691","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]},"assertion":[{"value":"2025-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02691"}}