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Given the insidious nature of periodontal tissue destruction, early diagnosis of periodontitis is crucial. Salivary hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) has been identified as a potential biomarker for periodontitis monitoring. However, existing detection methods struggle to precisely locate the source of H\n                    <jats:sub>2<\/jats:sub>\n                    S release within the oral cavity, making it difficult to accurately identify affected areas and significantly hindering early diagnosis and treatment of periodontitis. This study reports a visual aggregation\u2010induced emission (AIE) fluorescent probe (\n                    <jats:bold>TTN<\/jats:bold>\n                    ), which exhibits high sensitivity and rapid responsiveness to H\n                    <jats:sub>2<\/jats:sub>\n                    S, along with dual\u2010signal response capabilities in color and fluorescence. Based on this probe, a highly reliable and practical\n                    <jats:bold>TTN<\/jats:bold>\n                    film sensor capable of efficiently monitoring H\n                    <jats:sub>2<\/jats:sub>\n                    S is developed. The film can be used for real\u2010time diagnosis of periodontitis, allowing precise identification of diseased tooth areas through visible color and fluorescence changes. Additionally, the film demonstrates efficient reactive oxygen species (ROS) generation, inhibiting the growth of periodontitis\u2010causing bacteria and showcasing therapeutic potential. This integrated diagnostic and therapeutic design not only provides a novel approach for monitoring H\n                    <jats:sub>2<\/jats:sub>\n                    S as a biomarker but also opens new avenues for precise diagnosis and treatment of periodontitis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502710","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:51:03Z","timestamp":1758804663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["On\u2010Site Visualized Periodontitis Screening via Dual\u2010Signal H\n                    <sub>2<\/sub>\n                    S Probe"],"prefix":"10.1002","volume":"15","author":[{"given":"Wenqiang","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi 710061 P. R. China"},{"name":"Frontier Institute of Science and Technology Interdisciplinary Research Center of Frontier science and technology State Key Laboratory for Strength and Vibration of Mechanical Structures Engineering Research Center of Key Materials for Efficient Utilization of Clean Energy of Shaanxi Province Xi'an Key Laboratory of Electronic Devices and Material Chemistry Institute of New Concept Sensors and Molecular Materials Shaanxi Key Laboratory of New Conceptual Sensors and Molecular Materials Xi'an..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ding","sequence":"additional","affiliation":[{"name":"Frontier Institute of Science and Technology Interdisciplinary Research Center of Frontier science and technology State Key Laboratory for Strength and Vibration of Mechanical Structures Engineering Research Center of Key Materials for Efficient Utilization of Clean Energy of Shaanxi Province Xi'an Key Laboratory of Electronic Devices and Material Chemistry Institute of New Concept Sensors and Molecular Materials Shaanxi Key Laboratory of New Conceptual Sensors and Molecular Materials Xi'an..."},{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi 710049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology  Kowloon Hong Kong 999077 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Frontier Institute of Science and Technology Interdisciplinary Research Center of Frontier science and technology State Key Laboratory for Strength and Vibration of Mechanical Structures Engineering Research Center of Key Materials for Efficient Utilization of Clean Energy of Shaanxi Province Xi'an Key Laboratory of Electronic Devices and Material Chemistry Institute of New Concept Sensors and Molecular Materials Shaanxi Key Laboratory of New Conceptual Sensors and Molecular Materials Xi'an..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry State Key Laboratory of Marine Pollution City University of Hong Kong  Hong Kong 999077 P. R. 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