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Here, the development of COSnPPOD (CaO\n                    <jats:sub>2<\/jats:sub>\n                    \u2013Silica NP Platform for Osteogenic Development) is reported, a visible light digital light processing\u2010printed hydrogel scaffold that integrates oxygen\u2010releasing nanoparticles (NPs) within a Primitive\u2010type triply periodic minimal surface architecture. The scaffold combines a gelatin methacrylate\u2010poly(ethylene glycol) diacrylate matrix with calcium peroxide (CaO\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010loaded hollow silica NPs, enabling localized, short\u2010term oxygen release while preserving structural fidelity. COSnPPOD scaffolds demonstrate favorable degradation kinetics, tunable stiffness, and increased protein adsorption in vitro. In a preosteoblast model, COSnPPOD maintains cell viability and supports osteogenic gene expression without cytotoxic effects. While overall gene expression is comparable to controls, a 16\u2010fold increased expression of phosphoprotein 1 (Spp1) suggests scaffold\u2010driven activation of matrix remodeling pathways. In vivo, COSnPPOD scaffolds enhance bone regeneration in a murine calvarial defect model, with significantly greater bone formation and collagen deposition than untreated defects and hydrogel controls. Additionally, vascular endothelial growth factor immunostaining is increased within the defect, consistent with a proangiogenic response, and no systemic toxicity is observed. These findings establish COSnPPOD as a promising scaffold system that combines sustained oxygenation with biomimetic geometry to support localized bone regeneration.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502735","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:11:56Z","timestamp":1758633116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Visible Light Induced DLP\u2010Printed Oxygen\u2010Releasing TPMS Scaffolds Mitigate Early Hypoxia in Bone Defects"],"prefix":"10.1002","volume":"15","author":[{"given":"Anastasia B.","family":"Timoshenko","sequence":"first","affiliation":[{"name":"Walker Department of Mechanical Engineering The University of Texas at Austin  Austin TX 78712 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ghasemkhani","sequence":"additional","affiliation":[{"name":"Walker Department of Mechanical 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