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However, the immunosuppressive tumor microenvironment markedly impairs the antigen\u2010presenting capacity of dendritic cells (DCs), resulting in the inefficient presentation of locally generated antigens and, consequently, suboptimal immune responses. To address this challenge, a localized in situ vaccine platform (Gel\/MTO&amp;Snp) designed is developed to actively transport tumor\u2010derived antigens to tumor\u2010draining lymph nodes (tDLNs), thereby eliciting potent antitumor immunity. Gel\/MTO&amp;Snp consists of a thermosensitive hydrogel incorporating subsized PEI\/CpG nanocomposite particles (Snp, \u224810 nm) and chemotherapeutic agent mitoxantrone (MTO). Upon near\u2010infrared (NIR) laser irradiation, Gel\/MTO&amp;Snp simultaneously achieved photothermal and chemotherapeutic effects following local injection, thereby inducing immunogenic cell death and triggering antigen release at tumor sites. These liberated antigens are subsequently adsorbed onto positively charged Snp particles and transported via lymphatic vessels to tDLNs in a size\u2010dependent manner, where they enhanced antigen presentation and immune activation. This targeted antigen delivery markedly promotes DC maturation and effectively stimulates systemic anticancer immunity, providing a novel strategy to optimize the efficacy of in situ cancer vaccines.<\/jats:p>","DOI":"10.1002\/adhm.202502747","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T06:23:42Z","timestamp":1758090222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thermosensitive Hydrogel In Situ Vaccine for Lymph Node Targeting and Enhanced Immunotherapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Zhengyang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Oncology the First Affiliated Hospital of Anhui Medical University  Hefei Anhui 230022 P. R. 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