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The development of 3D printing provides a promising solution for corneal tissue engineering, offering precise control over dimensionality, structural organization, and cell\u2013matrix interactions. The choice of biomaterials and printing strategies critically determines the properties of 3D\u2010printed corneal constructs. While prior reviews have summarized general bioinks and techniques, few have addressed cornea\u2010specific benchmarks such as transparency, curvature, and mechanical robustness. This review provides a comprehensive discussion on the current study of 3D printed cornea, with a focus on replicating the biomechanical and optical properties of native human cornea. Key limitations in current fabrication methods are outlined, and recent advancements in 3D bioprinting technologies\u2014many of which have been successfully applied in other tissue engineering contexts\u2014are reviewed for their potential in producing anisotropic, multilayered corneal constructs with high resolution and fidelity. 3D printing human cornea is believed to have strong potential in generating scalable and clinically relevant solutions to overcome the global donor cornea tissue shortage, and 3D printing holds a central role in their development.<\/jats:p>","DOI":"10.1002\/adhm.202502767","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T05:37:26Z","timestamp":1759469846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["3D Printing Strategies for Bioengineering Human Cornea"],"prefix":"10.1002","volume":"15","author":[{"given":"Yunong","family":"Yuan","sequence":"first","affiliation":[{"name":"School of Medical Sciences Faculty of Medicine and Health University of Sydney  Camperdown Sydney NSW 2050 Australia"},{"name":"Charles Perkins Centre The University of Sydney  Camperdown Sydney NSW 2050 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoon S.","family":"Lim","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Medicine and Health University of Sydney  Camperdown Sydney NSW 2050 Australia"},{"name":"Charles Perkins Centre The University of Sydney  Camperdown Sydney NSW 2050 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Sutton","sequence":"additional","affiliation":[{"name":"Save Sight Institute University of Sydney  Sydney NSW 2000 Australia"},{"name":"Vision Eye Institute  Chatswood Sydney NSW 2067 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-7273","authenticated-orcid":false,"given":"Gordon G.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Intelligent Polymer Research Institute Innovation Campus University of Wollongong  Squires Way North Wollongong NSW 2500 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"You","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Medicine and Health University of Sydney  Camperdown Sydney NSW 2050 Australia"},{"name":"Save Sight Institute University of Sydney  Sydney NSW 2000 Australia"},{"name":"School of Optometry and Vision Science University of New South Wales  Sydney NSW 2033 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.07.001"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1065460"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123409"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.36922\/ijb.1669"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301506"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgab168"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.04.034"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2019.04.018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.10.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4798"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3181783a70"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq3917"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124510"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.01.023"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5920"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.95.4.649"},{"key":"e_1_2_9_17_1","first-page":"2244","volume":"32","author":"Komai Y.","year":"1991","journal-title":"Invest. 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