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Here, the feasibility of carboxymethyl cellulose hydrogel modified with pyrogallol (CMC\u2010PG) is checked for injection laryngoplasty. CMC\u2010PG, owing to its low viscosity, is easily injectable in liquid form and can self\u2010polymerize into a hydrogel without the need for oxidative cross\u2010linking agents. Moreover, the CMC\u2010PG hydrogel demonstrates improved stability, tissue adhesiveness, and elastic modulus, compared to a commercial product currently being used for injection laryngoplasty. CMC\u2010PG hydrogel has high binding affinity to various functional moieties and can maintain its structure under swelling condition for an extended period, thereby enabling sustained release of growth factors. CMC\u2010PG is highly biocompatible both in vitro and in vivo, and it does not induce fibrosis or immunogenic responses. Injection of CMC\u2010PG hydrogel encapsulating basic fibroblast growth factor (bFGF) regenerates both the lamina propria and the muscle layer in the vocal folds of an aged rat model, showing increased hyaluronic acids layer and muscle density, enhanced angiogenesis, and modulated immunogenicity. Importantly, bFGF\u2010loaded CMC\u2010PG hydrogel facilitates functional restoration of the aged vocal folds. This study offers clinical potential of CMC\u2010PG hydrogel for injection laryngoplasty for the treatment of presbylaryngis.<\/jats:p>","DOI":"10.1002\/adhm.202502787","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:55:45Z","timestamp":1761663345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tunicate\u2010Inspired Carboxymethyl Cellulose Hydrogel Filler for Treating Age\u2010Associated Vocal Fold Atrophy"],"prefix":"10.1002","volume":"15","author":[{"given":"Jihoon","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Biotechnology Yonsei University  Seoul 03722 Republic of Korea"},{"name":"CellArtgen Inc.  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