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Although hand\u2010sewn sutures are the current standard of care, their use to close liver injuries has numerous challenges. In this study, we constructed a Janus adhesive patch using a one\u2010step gradient cross\u2010linking method that enables effective, rapid, robust, and suture\u2010free repair of liver injuries. The patch features strong adhesiveness on one side and non\u2010adhesiveness on the other, allowing effective adhesion to liver injury sites while preventing adhesion to healthy tissues. Furthermore, this patch exhibited excellent mechanical properties aligned with the requirements for tissue repair. We compared its repair effectiveness to sutures and commercially available tissue adhesives (FuAiLe: FAL) in a mouse liver injury model and evaluated its efficacy and repair performance through blood tests and histological analysis. 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