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However, dendritic cells frequently exhibit compromised antigen\u2010presenting capabilities and adopt an immunoregulatory or tolerogenic phenotype, contributing to immune suppression in tumor microenvironment, severely limiting their efficacy. To overcome this, a pH\u2010responsive lung\u2010metastasis\u2010targeted wirelessly charging\u2010boosted dual\u2010catalyst nanoplatform composed of tumor\u2010penetrating solid lipids\/polymer\u2010coated N\u2010doped carbon dots\/mesoporous silica nanoparticles (CMS), loaded with cuproptosis\u2010inducing agents (elesclomol\u2013copper, EsCu) is developed for initiating a self\u2010cascade immune response and dendritic cell retention. Upon exposure to alternating magnetic fields (AMFs), N\u2010doped carbon dots can generate the currents and enhance cuproptosis through mechanisms consistent with Kelvin's force laws, boosting catalytic activity. Intravenously injected CMS selectively accumulates at metastatic tumor sites through pH\u2010triggered charge switching, while the positive charge also promotes the release of cell\u2013cell interactions. At tumor site, Es and Cu are released in response to intracellular conditions and AMF stimulation, inducing cuproptosis in cancer cells and disrupting immune evasion. This cytotoxicity is paired with in situ antigen release, which CMS carriers deliver to reprogram DCs, initiating sustained immune activation. When combined with immune checkpoint blockade (anti\u2010PD\u20101), the CMS system effectively suppresses lung metastases and extends survival beyond 60 days.<\/jats:p>","DOI":"10.1002\/adhm.202502817","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:14:27Z","timestamp":1762326867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Electromagnetic Wireless Remote Control of Reprogramming Immune Dysfunction via N\u2010Doped Carbon Dots\u2013Mesoporous Silica\u2010Mediated Cuproptosis and Dendritic Cell Retention"],"prefix":"10.1002","volume":"15","author":[{"given":"Hui\u2010Wen","family":"Lien","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 300044 Taiwan"},{"name":"National Institute of Cancer Research National Health Research Institutes  Miaoli County 35053 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Yen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 300044 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Hsuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 300044 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi My Hue","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 300044 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhanu Nirosha","family":"Yalamandala","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 300044 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung Chin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 300044 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoi\u2010Man","family":"Iao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 300044 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Chi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 300044 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Yueh\u2010Luen","family":"Lee","sequence":"additional","affiliation":[{"name":"National Institute of Cancer Research National Health Research Institutes  Miaoli County 35053 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hsuan","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Chung Hsing University  Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-3918","authenticated-orcid":false,"given":"Shang\u2010Hsiu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 300044 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c05395"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202211698"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401806"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007557"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09601"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2025.102838"},{"key":"e_1_2_8_7_1","first-page":"170","volume":"9","author":"Chu X.","year":"2024","journal-title":"Chin. 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