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Alternatively, while existing tissue adhesives can seal and adhere to wounds, they may cause immunogenic responses, tissue necrosis, restricted movement, and wound disruption upon removal, leading to secondary injuries and scarring. Herein, injectable poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA)\u2010dopamine (DA) hydrogels co\u2010crosslinked via hydrazone linkages and dopamine self\u2010polymerization are fabricated that promote high water retention, effective tissue adhesion, re\u2010epithelialization, and functional skin regeneration. The dual crosslinking mechanism allows for gelation as fast as 24\u00a0s (enabling injection and rapid filling of irregularly\u2010shaped wounds) while achieving compressive moduli of up to 37\u00a0kPa and skin adhesion strengths of up to 3.3\u00a0kPa. In a 14\u2010day stented mouse skin wound model, the POEGMA\u2010DA hydrogels induce no significant inflammation, effective tissue adhesion, and promote tissue regeneration, including enhanced collagen remodelling, 3\u20135\u00d7 higher hair follicle, \u22485\u20137\u00d7 higher sebaceous gland and 1.5\u20131.7\u00d7 higher blood vessel regeneration at the excision site compared to untreated wounds. These hydrogels represent an alternative nontoxic wound closure system that mimics the soft skin tissue environment to promote regeneration after acute superficial dermal wounds.<\/jats:p>","DOI":"10.1002\/adhm.202502866","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T06:00:07Z","timestamp":1760508007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Injectable Dual\u2010Crosslinked Poly(oligo(Ethylene Glycol) Methacrylate) Hydrogels Inspired by Mussel Adhesion for Cutaneous Wound Healing and Functional Tissue Regeneration"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7905-9712","authenticated-orcid":false,"given":"Gurpreet Kaur","family":"Randhawa","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering McMaster University  1280 Main Street West Hamilton Ontario L8S 4L8 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