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However, insufficient antigen exposure and presentation remain major obstacles for potent immunotherapy. Here, a novel metal\u2010polyphenol network\u2010coated human serum albumin nanoplatform (IMT@H) is engineered to co\u2010deliver IR780 and manganese ions (Mn\n                    <jats:sup>2+<\/jats:sup>\n                    ) to achieve enhanced immunogenic cell death (ICD) and cGAS\u2010STING\u2010dependent antigen presentation. The metal\u2010polyphenol nanostructure facilitates the pH\u2010responsive release of Mn\n                    <jats:sup>2+<\/jats:sup>\n                    , which subsequently initiates Fenton\u2010like reactions to generate hydroxyl radicals (\u00b7OH). Meanwhile, under near\u2010infrared (NIR) light irradiation, IR780 induces mitochondrial\u2010targeted phototherapy and concurrently produces reactive oxygen species (ROS). These processes act synergistically to amplify the oxidative damage and ICD in TC\u20101 tumors, leading to the release of damage\u2010associated molecular patterns (DAMPs). These ICD\u2010derived DAMPs cooperate with Mn\n                    <jats:sup>2+<\/jats:sup>\n                    to sustain activation of the cGAS\u2010STING pathway in dendritic cells. This combinatorial strategy successfully transforms tumor antigens into endogenous vaccines, eventually inhibiting the growth of primary tumors and producing strong abscopal effects. Notably, mice primed with nanovaccines exhibit strong anti\u2010HPV16 E7\u2010specific immune responses and tumor resistance. With its dual therapeutic and preventive functionality, IMT@H represents a paradigm\u2010shifting strategy for virus\u2010driven malignancies and offers a blueprint for engineering self\u2010adjuvanting nanovaccines against viral oncogenesis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502884","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T05:17:47Z","timestamp":1759468667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["NIR\u2010Triggered Metal\u2010Polyphenol Nanoparticles Enhance HPV\u2010Driven Cancer Immunotherapy via Immunogenic Cell Death and STING Sequential Activation"],"prefix":"10.1002","volume":"15","author":[{"given":"Maoyu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Chongqing Medical University  Chongqing 400010 P. R. 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