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Herein, an aqueous phase\u2010synthesized gallium\u2010doped copper indium selenide quantum dot (QD) probe designed for grading TBI severity is introduced. The doping of gallium ions into the semiconductor core largely restrained the nonradiative recombination rate, thereby significantly enhancing the near\u2010infrared emission of the QDs. Surface modification strategies further improve QD stability and biocompatibility, ensuring high\u2010sensitivity imaging in vivo. In mouse models with varying TBI severities, intravenous administration of Ga\u2010doped QDs, combined with advanced imaging protocols and data analysis, achieved objective grading of injury severity through quantitative analysis of fluorescence signal intensity and distribution, demonstrating a remarkable correlation between QD\u2010derived signals and neuropathological severity. This grading result is further verified by a series of behavioral tests of the corresponding TBI mice. This QD\u2010based imaging strategy offers a sensitive and\u00a0objective tool for TBI assessment, enabling precise grading and dynamic monitoring, thereby improving clinical decision\u2010making. This innovation complements existing diagnostics and has transformative potential for optimizing TBI management and patient outcomes, especially in resource\u2010limited settings.<\/jats:p>","DOI":"10.1002\/adhm.202502911","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:04:01Z","timestamp":1753171441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Aqueous Gallium\u2010Doped Copper Indium Selenide Quantum Dots for Non\u2010Invasive Severity Grading of Traumatic Brain Injury"],"prefix":"10.1002","volume":"14","author":[{"given":"Xiao","family":"Sun","sequence":"first","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanru","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiye","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichen","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peisen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Jiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6075-7089","authenticated-orcid":false,"given":"Xiliang","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00309-X"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj4260"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06702-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS17352"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0000000000000026"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699052.2020.1763467"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2021.10.013"},{"key":"e_1_2_8_8_1","first-page":"1008","volume":"66","author":"Manolakaki D.","year":"2009","journal-title":"J. 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