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The developed MACD nGel is synthesized by free radical polymerization and successfully loaded with MNZ. The nGel\/MNZ system is shown to be effective against the main causative organisms of periodontitis,\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    (\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    ) and\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    (\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    ), and shows significant bacteriostatic effects and good cytocompatibility. In animal studies, the topical application of nGel\/MNZ significantly attenuates the inflammatory response in periodontitis, reduces the expression of key inflammatory factors interleukin 1 beta (IL\u20101\u03b2) and tumor necrosis factor alpha (TNF\u2010\u03b1), and improves the balance of the microbial composition of gingival crevicular fluid (GCF). The study demonstrates that cyclodextrin nanogel (nGel) loaded with metronidazole not only provides an efficient drug delivery route but also has potential clinical applications and offers a novel strategy for the local treatment of periodontitis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502965","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:21:41Z","timestamp":1761664901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metronidazole\u2010Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4814-7648","authenticated-orcid":false,"given":"Yanjing","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Biomaterials and Biomedical Technology University Medical Center Groningen University of Groningen  Ant. 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