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While xenografts such as deproteinized bovine bone mineral are commonly used, they are characterized by slow resorption and limited biological activity. Herein, \u201cAquaGraft\u201d is introduced, a fully resorbable, bioactive bone graft composite derived from bullfrog skin collagen and fish\u2010scale hydroxyapatite, engineered into a dual\u2010crosslinked, hierarchically porous structure. Ex vivo whole\u2010blood hemostasis assays revealed significantly faster clot formation with AquaGraft compared to Bio\u2010Oss\n                    <jats:sup>\u00ae<\/jats:sup>\n                    Collagen. In canine model, AquaGraft showed complete resorption within 16 weeks, and supported continuous, mineralized bone bridging with no observable graft remnants. AquaGraft demonstrated equivalent ridge preservation performance to Bio\u2010Oss\n                    <jats:sup>\u00ae<\/jats:sup>\n                    \u00a0Collagen, while offering a distinct advantage in promoting 3D vascular network formation, important for long\u2010term graft integration. Quantitative imaging revealed comparable buccal ridge preservation (AquaGraft: 86.08% \u00b1 3.82%, Bio\u2010Oss\n                    <jats:sup>\u00ae<\/jats:sup>\n                    Collagen: 87.24% \u00b1 3.87%) and new bone formation (AquaGraft: 44.90% \u00b1 4.63%, Bio\u2010Oss\n                    <jats:sup>\u00ae<\/jats:sup>\n                    Collagen: 54.91% \u00b1 3.66%), despite AquaGraft's lower hydroxyapatite content. This suggests a more efficient coupling of mineral reinforcement with biological remodeling, facilitated by its collagen\u2010rich, pro\u2010regenerative matrix. Overall, these findings position AquaGraft as a clinically translatable, bio\u2010resorbable and bioinstructive scaffold capable of guiding bone tissue regeneration.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503001","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:20:36Z","timestamp":1762410036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hierarchically Structured Aquatic Collagen\u2013Hydroxyapatite Matrices for Targeted Alveolar Ridge Regeneration"],"prefix":"10.1002","volume":"15","author":[{"given":"Huaqi","family":"Cao","sequence":"first","affiliation":[{"name":"China\u2010Singapore International Joint Research Institute (CSIJRI) China Singapore Guangzhou Knowledge City Huangpu Guangzhou 510555 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjin","family":"Zeng","sequence":"additional","affiliation":[{"name":"China\u2010Singapore International Joint Research Institute (CSIJRI) China Singapore Guangzhou Knowledge City Huangpu Guangzhou 510555 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Kit","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Nanyang Technological University  N4.1 50 Nanyang Avenue Singapore 639798 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6721-7106","authenticated-orcid":false,"given":"Chor Yong","family":"Tay","sequence":"additional","affiliation":[{"name":"China\u2010Singapore International Joint Research Institute (CSIJRI) China Singapore Guangzhou Knowledge City Huangpu Guangzhou 510555 P. R. 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