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Nonetheless, cellular contaminants and tissue ingrowth remain significant challenges for implantable ISF devices. Herein, a vapor\u2010based porous coating technology is proposed, capable of producing a mechanically durable and homogeneous porous layer within the internal lumen of a nitinol tube. Biochemically, the coating prevents the ingrowth of cells or tissues into the porous structure while simultaneously ensuring the desired filtration performance of the ISF. The porous coating layers are thoroughly examined with respect to their ability to transport molecules. A variety of model probing molecules are loaded\/encapsulated within the layered configuration to understand the molecular diffusion kinetics and transport phenomenon in the proposed porous coatings. Furthermore, in vitro and in vivo assessments of the interstitial fluids are used to validate the transport of biomolecules within the porous coatings. Moreover, when the perforated nitinol tube is incorporated, the filtration efficiency is &gt; 80% for particles larger than 500\u00a0nm, and more than 98% of the particles larger than 1000\u00a0nm are retained during the filtration of these coatings.<\/jats:p>","DOI":"10.1002\/adhm.202503040","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T07:11:13Z","timestamp":1762153873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Porous Coatings by Vapor Sublimation and Deposition for Molecular Channeling and Filtration in an Interstitial Fluid Microfiltration Device"],"prefix":"10.1002","volume":"15","author":[{"given":"Yu\u2010Ming","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"GiMer Medical Company Limited  New Taipei City 22175 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Jia","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Hui","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology | Department of Medical Research National Taiwan University Hospital | National Taiwan University Hospital Hsin\u2010Chu Branch  Taipei | Hsinchu 10018 | 302058 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Chang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology | Department of Medical Research National Taiwan University Hospital | National Taiwan University Hospital Hsin\u2010Chu Branch  Taipei | Hsinchu 10018 | 302058 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chih","family":"Chiang","sequence":"additional","affiliation":[{"name":"School of Dentistry Graduate Institute of Clinical Dentistry National Taiwan University and National Taiwan University Hospital Taipei 10048 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Chi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology | Department of Medical Research National Taiwan University Hospital | National Taiwan University Hospital Hsin\u2010Chu Branch  Taipei | Hsinchu 10018 | 302058 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-6680","authenticated-orcid":false,"given":"Hsien\u2010Yeh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,2]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00998-9"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202201763"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw0285"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.3c02279"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c06688"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2024.101277"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/09544119221123176"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071794"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01739-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40544-023-0850-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100403"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.1c00063"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cben.202300027"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c16463"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264825"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(83)90064-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051364"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00380"},{"key":"e_1_2_9_19_1","first-page":"363","volume":"15","author":"Korkmaz Y.","year":"2022","journal-title":"J. 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