{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:57:58Z","timestamp":1791482278634,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Early diagnosis of Alzheimer's disease (AD) is hindered by the high cost, complexity, and centralization of current diagnostic platforms such as enzyme\u2010linked immunosorbent assay (ELISA) and single\u2010molecule array (SIMOA). Here, an integrated point\u2010of\u2010care (PoC) biosensing platform is reported based on redox\u2010active polyphenol red molecularly imprinted polymers (pPhR MIPs) deposited on highly porous gold (HPG) electrodes for the ultrasensitive, reagent\u2010free detection of phosphorylated tau 181 (p\u2010tau 181) in undiluted plasma and serum. The unique electrochemical interface combines the signal\u2010enhancing properties of HPG with the redox functionality of pPhR, eliminating the need for external redox probes. The resulting sensor achieves a limit of detection (LOD) of 980\u00a0fg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    and sensitivity of 4.39\u00a0\u00b5A\/(pg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), rivalling high\u2010end lab\u2010based assays while operating at a fraction of the cost. The platform integrates a low\u2010cost, handheld potentiostat and a machine learning (ML)\u2010enabled web app for real\u2010time data classification and regression, achieving 100% classification accuracy with zero false positives or negatives. The system demonstrates compatibility with both ethylenediaminetetraacetic acid (EDTA) and heparin\u2010treated samples and maintains accuracy in complex matrices. This work represents a step toward World Health Organization (WHO)\u2010compliant, decentralized diagnostics for neurodegenerative disease, offering a scalable foundation for future multianalyte platforms targeting AD and related disorders.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503155","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T11:26:54Z","timestamp":1756985214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Redox\u2010Active Polyphenol Red Molecularly Imprinted Polymers on Porous Gold Electrodes for Ultrasensitive, AI\u2010Assisted Detection of Alzheimer's Biomarkers in Undiluted Biofluids"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9711-1120","authenticated-orcid":false,"given":"Sudhaunsh","family":"Deshpande","sequence":"first","affiliation":[{"name":"David Price Evans Global Health and Infectious Diseases Group Pharmacology &amp; Therapeutics Institute of Systems Molecular and Integrative Biology University of Liverpool  Crown Street Liverpool L69 7BE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6781-2108","authenticated-orcid":false,"given":"Ajith Mohan","family":"Arjun","sequence":"additional","affiliation":[{"name":"David Price Evans Global Health and Infectious Diseases Group Pharmacology &amp; Therapeutics Institute of Systems Molecular and Integrative Biology University of Liverpool  Crown Street Liverpool L69 7BE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyi","family":"Liu","sequence":"additional","affiliation":[{"name":"David Price Evans Global Health and Infectious Diseases Group Pharmacology &amp; Therapeutics Institute of Systems Molecular and Integrative Biology University of Liverpool  Crown Street Liverpool L69 7BE UK"},{"name":"Key Laboratory of Optoelectronic Technology &amp; Systems (Chongqing University)  Chongqing 400044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kryztof","family":"Pawlak","sequence":"additional","affiliation":[{"name":"Materials Innovation Factory University of Liverpool  51 Oxford Street Liverpool L7 3NY UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3828-737X","authenticated-orcid":false,"given":"Sanjiv","family":"Sharma","sequence":"additional","affiliation":[{"name":"David Price Evans Global Health and Infectious Diseases Group Pharmacology &amp; Therapeutics Institute of Systems Molecular and Integrative Biology University of Liverpool  Crown Street Liverpool L69 7BE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"What Is Alzheimer's Disease? 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