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The Golgi apparatus is involved in the occurrence and development of cardiovascular diseases. In this work, a dual\u2010responsive fluorescent probe\n                    <jats:bold>GHO<\/jats:bold>\n                    , which can detect simultaneously both Golgi superoxide anion (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    ) and peroxynitrite anion (ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) with two distinct emission bands, is developed for investigating the Golgi stress\u2010mediated myocardial injury mechanism. Furthermore, a synthesized hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) donor (\n                    <jats:bold>GADT<\/jats:bold>\n                    ) with Golgi apparatus targeting ability is used for intervening the process of Dox\u2010induced cardiac damage, which shows significant antioxidant capacity in the Golgi apparatus with the help of evaluation of the probe\n                    <jats:bold>GHO<\/jats:bold>\n                    . In detail, compound\n                    <jats:bold>GADT<\/jats:bold>\n                    inhibits Golgi apparatus stress by clearing reactive oxygen species (ROS), thus recover the myocardial damage caused by Dox in cardiomyocytes, zebrafish, and mice. Finally,\n                    <jats:bold>GADT<\/jats:bold>\n                    is proven to play an effective therapeutic role by promoting the degradation of the damaged Golgi apparatus into an autophagosome. Therefore, focusing on the Golgi apparatus, development of the small molecule fluorescent probe\n                    <jats:bold>GHO<\/jats:bold>\n                    and the Golgi\u2010targeting H\n                    <jats:sub>2<\/jats:sub>\n                    S donor\n                    <jats:bold>GADT<\/jats:bold>\n                    provides a novel perspective for the diagnosis and treatment of Dox\u2010induced myocardial injury mechanism.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503158","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:32:23Z","timestamp":1756467143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fabrication of a Dual\u2010Responsive Fluorescence Probe for Monitoring Cardiac Injury and Repairing by a Golgi\u2010Targeting Hydrogen Sulfide Donor"],"prefix":"10.1002","volume":"14","author":[{"given":"Ao","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study Hengyang Medical School University of South China  Hengyang 421001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study Hengyang Medical School University of South China  Hengyang 421001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study Hengyang Medical School University of South China  Hengyang 421001 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longwei","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmacy Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study Hengyang Medical School University of South China  Hengyang 421001 P. R. China"},{"name":"School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang 453007 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9952-1089","authenticated-orcid":false,"given":"Linxi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study Hengyang Medical School University of South China  Hengyang 421001 P. R. 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