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To mitigate these drawbacks, a novel nano\u2010vaccine platform was developed by incorporating immunostimulatory oncolytic adenoviruses within tumor cell membranes. This biomimetic system enabled sustained antigen release and tumor\u2010localized delivery of co\u2010stimulatory molecules, creating immunological hotspots through in situ viral replication and PANoptosis. The nano\u2010vaccine achieved selective viral tropism with a 36.3:1 tumor\u2010to\u2010liver biodistribution ratio (vs. 1.0:1 for the uncoated virus) while resisting immune\/ascites interference. Oncolysis triggered immunogenic cell death, which released damage\u2010associated molecular patterns and drove systemic antitumor immunity. Notably, the platform enriched stem\u2010like TCF1\n                    <jats:sup>+<\/jats:sup>\n                    PD\u20101\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell reservoirs that demonstrate enhanced effector differentiation upon PD\u20101 checkpoint blockade. In models of peritoneal carcinomatosis, combination therapy with \u03b1PD\u20101 induced complete tumor eradication in 50% of mice and significantly prolonged survival. Furthermore, a synergistic efficacy was observed when the nano\u2010vaccine was administered with cisplatin, a frontline chemotherapeutic agent. This virotherapy paradigm synergizes vaccination and immune reprogramming to dismantle immunosuppressive networks, thereby offering transformative potential against ovarian cancer.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503175","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:12:12Z","timestamp":1768893132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Tumor Cell Membrane\u2010Coated CD40 Ligand\u2010Encoding Oncolytic Adenovirus Serves as a Potent Nano\u2010Vaccine for Ovarian Cancer Immunotherapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"National Clinical Research Centre for Obstetrics and Gynecology Cancer Biology Research 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