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Inspired by natural budding phenomena, this study developed solvent\u2010free tannic acid\u2013polyethylene oxide (TA\u2010PEO) microcapsules with tunable surface roughness, achieved through an interfacial instability mechanism triggered by bovine serum albumin (BSA). The microfluidic platform enables precise control of microcapsule size and monodispersity through vibration frequency and flow rate optimization. The dynamic hydrogen\u2010bonded TA\u2010PEO network facilitates pH\u2010responsive drug release, which can be tuned from burst to sustained modes through polyethylene oxide (PEO) concentration adjustments. Competitive BSA adsorption at the capsule interface generates localized \u201csoft patches,\u201d triggering spontaneous budding under osmotic gradients. This roughness significantly enhances intestinal adhesion, with budding microcapsules exhibiting prolonged retention in vivo compared with their smooth counterparts. 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