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The\n                    <jats:bold>IMD\u2010006<\/jats:bold>\n                    dendrimer exhibits promising immunomodulatory effects, but optimized formulations are needed to improve skin penetration. This study describes fluid vesicle formulations to enhance\n                    <jats:bold>IMD\u2010006<\/jats:bold>\n                    delivery and evaluates their anti\u2010psoriatic efficacy in a murine model, offering potential for innovative topical therapies. Due to\n                    <jats:bold>IMD\u2010006<\/jats:bold>\n                    \u2019s hydrolytic instability at pH 7, more stable analogues,\n                    <jats:bold>IMD\u2010036<\/jats:bold>\n                    and\n                    <jats:bold>IMD\u2010046<\/jats:bold>\n                    , are designed with phosphoramidate and triazine branching points, improving hydrolytic resistance. Fluorescent derivatives are also synthesized using copper\u2010free click chemistry for biological studies. These dendrimers are actively internalized by monocytes, promoting an anti\u2010inflammatory phenotype. Encapsulation in highly fluid\n                    <jats:bold>TriCat<\/jats:bold>\n                    catanionic vesicles significantly enhances cellular uptake and skin penetration, particularly for\n                    <jats:bold>IMD\u2010006<\/jats:bold>\n                    and\n                    <jats:bold>IMD\u2010036<\/jats:bold>\n                    , facilitating deeper tissue diffusion without systemic exposure. A xanthan\u2010based hydrogel incorporating\n                    <jats:bold>TriCat<\/jats:bold>\n                    vesicles loaded with these dendrimers is developed for topical application, improving stability, sustained drug release, and skin permeability. In a psoriatic mouse model,\n                    <jats:bold>TriCat\/IMD\u2010006<\/jats:bold>\n                    and\n                    <jats:bold>TriCat\/IMD\u2010036<\/jats:bold>\n                    formulations significantly reduced disease severity (\u00a0\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001 and\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05 respectively), producing clinical and histopathological outcomes equivalent to corticosteroid treatment. These findings highlight the potential of dendrimer\u2010based formulations as effective topical treatments for psoriasis, offering an alternative to conventional corticosteroids.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503282","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:51:48Z","timestamp":1764831108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased Anti\u2010Psoriatic Effect of Anti\u2010Inflammatory Dendrimers Using Fluid Catanionic Vesicle\u2010Based Topical Formulations"],"prefix":"10.1002","volume":"15","author":[{"given":"Ranime","family":"Jebbawi","sequence":"first","affiliation":[{"name":"Laboratoire Softmat, Universit\u00e9 de Toulouse CNRS UMR 5623 Toulouse France"},{"name":"Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy) Universit\u00e9 de Toulouse INSERM UMR1291 \u2013 CNRS UMR5051 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelouahd","family":"Oukhrib","sequence":"additional","affiliation":[{"name":"Laboratoire Softmat, Universit\u00e9 de Toulouse CNRS UMR 5623 Toulouse France"},{"name":"Laboratoire De Chimie de Coordination (LCC) Universit\u00e9 de Toulouse CNRS UPR 8241 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Clement","sequence":"additional","affiliation":[{"name":"Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy) Universit\u00e9 de Toulouse INSERM UMR1291 \u2013 CNRS UMR5051 Toulouse France"},{"name":"IMD\u2010Pharma  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Labie","sequence":"additional","affiliation":[{"name":"Laboratoire Softmat, Universit\u00e9 de Toulouse CNRS UMR 5623 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Cassel","sequence":"additional","affiliation":[{"name":"Laboratoire Softmat, Universit\u00e9 de Toulouse CNRS UMR 5623 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Fruchon","sequence":"additional","affiliation":[{"name":"Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy) Universit\u00e9 de Toulouse INSERM UMR1291 \u2013 CNRS UMR5051 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Caminade","sequence":"additional","affiliation":[{"name":"Laboratoire De Chimie de Coordination (LCC) Universit\u00e9 de Toulouse CNRS UPR 8241 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Simon","sequence":"additional","affiliation":[{"name":"Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy) Universit\u00e9 de Toulouse INSERM UMR1291 \u2013 CNRS UMR5051 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Poupot","sequence":"additional","affiliation":[{"name":"Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy) Universit\u00e9 de Toulouse INSERM UMR1291 \u2013 CNRS UMR5051 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-8070","authenticated-orcid":false,"given":"C\u00e9dric\u2010Olivier","family":"Turrin","sequence":"additional","affiliation":[{"name":"Laboratoire De Chimie de Coordination (LCC) Universit\u00e9 de Toulouse CNRS UPR 8241 Toulouse France"},{"name":"IMD\u2010Pharma  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5286-448X","authenticated-orcid":false,"given":"Muriel","family":"Blanzat","sequence":"additional","affiliation":[{"name":"Laboratoire Softmat, Universit\u00e9 de Toulouse CNRS UMR 5623 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-024-02481-1"},{"key":"e_1_2_8_3_1","first-page":"558","article-title":"Psoriasis: Update on Topical Therapy from the American Academy of Dermatology","volume":"105","author":"Shreiber A. 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