{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:19:01Z","timestamp":1786976341581,"version":"build-2736575974"},"reference-count":77,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401181"],"award-info":[{"award-number":["82401181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201048"],"award-info":[{"award-number":["82201048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Peri\u2010implantitis (PI) is a common disease that occurs in most dental implant patients. The progressive bone resorption related to PI markedly affects patients\u2019 life quality. Thermosensitive hydrogels composed of chitosan (CS) and \u03b2\u2010glycerophosphate (GP) have been previously employed for the PI treatment. However, their restricted mechanical strength undermined the bone\u2010repairing outcome. The formation of a hybrid network by adding inorganic crosslinking components may help improve the mechanical properties of hydrogels. Moreover, copper (Cu) ions have been confirmed to be beneficial for bacterial killing in a concentration\u2010dependent manner. Hence, a copper chelated thermosensitive hybrid hydrogel (Cu\/CGT) is fabricated here by incorporating tetraethoxysilane into the Cu doped CS and GP solution. Material characterization, biocompatibility, and antibacterial tests are conducted in vitro and in vivo to determine the physical and biological properties of hydrogels. The result shows that 1Cu\/CGT with improved compressive modulus can not only promote the osteogenic differentiation and suppress the inflammation, but also show notable bacterial killing ability against pathogenic bacteria. The ideal Cu release profile of 1Cu\/CGT may contribute to the satisfactory biomedical performance of hydrogels. In summary, this study develops a thermosensitive hybrid hydrogel with ideal bacterial\u2010defensive and pro\u2010osteogenic performance, exhibiting good potential for clinical treatment of PI.<\/jats:p>","DOI":"10.1002\/adhm.202503315","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T06:43:52Z","timestamp":1769323432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Copper\u2010Chelated Thermosensitive Hybrid Hydrogels for Peri\u2010Implantitis Treatment"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1601-0871","authenticated-orcid":false,"given":"Xinxin","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Oral Implantology Shanghai Ninth People's Hospital School of Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Shanghai Ninth People's Hospital School of Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Shanghai Ninth People's Hospital School of Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Shanghai Ninth People's Hospital School of Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Shanghai Ninth People's Hospital School of Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beilei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Shanghai Ninth People's Hospital School of Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-3819","authenticated-orcid":false,"given":"Shujiao","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Shanghai Ninth People's Hospital School of Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114082"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12335"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16060769"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbae028"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116826"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S190781"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.05.033"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116196"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111555"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235960"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.07.019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj7857"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coche.2019.02.010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB00767D"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3TB21507E"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10111350"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2020.109984"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2012.11.026"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2003.10.004"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2021.08.035"},{"key":"e_1_2_9_22_1","first-page":"2020","article-title":"An Antibacterial Strategy of Mg\u2010Cu Bone Grafting in Infection\u2010Mediated Periodontics","volume":"28","author":"Zhao X.","year":"2020","journal-title":"BioMed Research International"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.04.012"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2018.04.007"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010017\u20109683\u20100"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500712"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics5040057"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2264"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117777"},{"issue":"21","key":"e_1_2_9_30_1","first-page":"1","article-title":"Nonchemotherapic and Robust Dual\u2010Responsive Nanoagents With On\u2010Demand Bacterial Trapping, Ablation, and Release for Efficient Wound Disinfection","volume":"28","author":"Yang Y.","year":"2018","journal-title":"Advanced Functional Materials"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c05859"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.100972"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.46459"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.04.010"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/coatings10060534"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2017.04.076"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35171"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8090535"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.02.028"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB00009D"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.04.009"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c01739"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.029"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2014.03.065"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13122"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2021.03.003"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37136"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111032"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.07.028"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.01.010"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB00009D"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.07.068"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.04.060"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e32850"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymertesting.2019.04.004"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2020.146069"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c03106"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.07.063"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110598"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11595\u2010011\u20100205\u20105"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2009.07.044"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12633\u2010020\u201000397\u20102"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800700"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2023.112229"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.130147"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301366"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37855"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208989"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12707"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.213158"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.08.038"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8562050"},{"key":"e_1_2_9_73_1","article-title":"In Vitro Evaluation of Bacterial Adhesion and Bacterial Viability of Streptococcus mutans, Streptococcus sanguinis, and Porphyromonas gingivalis on the Abutment Surface of Titanium and Zirconium Dental Implants","volume":"13","author":"Meza\u2010Siccha A. S.","year":"2019","journal-title":"International Journal of Dentistry"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.08.033"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2013.11.028"},{"issue":"1","key":"e_1_2_9_76_1","first-page":"1","article-title":"Multiscale Architecture Design of 3D Printed Biodegradable Zn\u2010Based Porous Scaffolds for Immunomodulatory Osteogenesis","volume":"15","author":"Li S.","year":"2024","journal-title":"Nature Communications"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.10.009"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201027217\u20104"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202503315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202503315","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202503315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:14:26Z","timestamp":1785453266000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202503315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":77,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/adhm.202503315"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202503315","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]},"assertion":[{"value":"2025-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03315"}}