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Herein, a biomimetic nanoplatform composed of macrophage membrane (MM)\u2010coated porous carbon nanospheres (MM@PCNSs) is developed for synergistic immunomodulation and targeted iguratimod (IGU) delivery in RA therapy. The PCNS core integrates multi\u2010enzyme mimetic activities for efficient reactive oxygen species (ROS) scavenging and supports high drug loading with pH\/NIR\u2010responsive release. Biomimetic macrophage membrane cloaking enables inflammation\u2010targeted delivery and in situ neutralization of cytokines. In vitro, MM@PCNSs\/IGU effectively reduced oxidative stress and inhibited pro\u2010inflammatory cytokines. In vivo, NIR\u2010activated MM@PCNSs\/IGU significantly alleviated synovial inflammation, reduced joint destruction, and improved clinical scores in collagen\u2010induced arthritis (CIA) mice. This multifunctional nanoplatform integrates targeted delivery, redox regulation, and immune reprogramming to overcome limitations of conventional therapies, offering a promising strategy for restoring synovial homeostasis and achieving durable remission in RA.<\/jats:p>","DOI":"10.1002\/adhm.202503316","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:10:21Z","timestamp":1761390621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Macrophage Membrane\u2010Coated Carbon Nanozymes for Targeted Drug Delivery and NIR\u2010Responsive Synergistic Therapy in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8826-5594","authenticated-orcid":false,"given":"Yuhuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics China\u2010Japan Union Hospital of Jilin University Changchun Jilin 130033 P. 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