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However, hostile post\u2010infarct microenvironments, characterized by oxidative stress and ischemia, significantly reduce stem cell retention and survival rates. Herein, an intramyocardially injectable and pH\u2010responsive (2\u2032 Z, 3\u2032 E)\u20106\u2010Bromoindirubin\u20103\u2032\u2010oxime (BIO)\u2010N\u2010adipose\u2010derived stem cells (ADSCs)\u2010Matrigel system is developed for treating AMI. Encapsulated ADSCs exhibited a high retention rate in myocardial tissue. Furthermore, BIO\u2010N exhibited a self\u2010feedback function, enabling it to modulate the release of BIO in response to pH changes in the microenvironment during the progression of AMI. This system effectively protected stem cells and cardiomyocytes from ROS\u2010induced injury while enhancing the therapeutic efficacy of ADSCs by improving their paracrine function. Subsequently, it is demonstrated that the BIO\u2010N\u2010ADSCs\u2010Matrigel system significantly reduced infarction size, mitigated fibrosis, and enhanced local angiogenesis in a rat model of AMI. The self\u2010feedback functional BIO\u2010N\u2010ADSCs\u2010Matrigel system can effectively mitigate local oxidative stress, enhance the survival rate and therapeutic efficacy of stem cells, and improve the viability of cardiomyocytes for AMI treatment.<\/jats:p>","DOI":"10.1002\/adhm.202503324","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:35:28Z","timestamp":1761284128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Injectable and pH\u2010Activated Self\u2010Feedback Hydrogel Encapsulating Stem Cells for Augmented Acute Myocardial Infarction Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Yan","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Human Anatomy Naval Medical University  Shanghai 200433 China"},{"name":"Department of Anatomy Anhui Medical University  Anhui 230032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy Naval Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine Translational Medicine Research Center &amp; Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices Naval Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy Naval Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine Translational Medicine Research Center &amp; Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices Naval Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Juan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy Naval Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy Naval Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy Naval Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy Naval Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Quan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy Naval Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-7364","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine Translational Medicine Research Center &amp; 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