{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:21:37Z","timestamp":1786976497383,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Uncontrolled hemorrhage is the leading cause of preventable death in both civilian and military populations. Current topical hemostats rely on packing the wound cavity, and\/or applying external pressure with pelvic binders. These methods have complications, need extensive training, necessitate surgical removal of hemostats, and lack an understanding of the chemical structure\u2010hemostatic property relationships. This work describes the design and testing of hemostatic electrospun patches (EPs) with carboxylic acid (\u2013COOH) and primary amine (\u2013NH\n                    <jats:sub>2<\/jats:sub>\n                    ) as procoagulant functional groups. EPs accelerate whole blood clotting in vitro, with \u2013COOH EPs performing almost twice as better compared to \u2013NH\n                    <jats:sub>2<\/jats:sub>\n                    EPs. In a mouse liver hemorrhage model, the EPs lower bleeding times by about 3 times compared to cotton gauze as control. The EPs restrict blood component flow and form a contracted, tissue\u2010adhesive clot at the EP\u2013wound interface due to its nanofibrous nature, thus mediating wound closure. On the other hand, cotton gauze fails to form a contracted clot at the gauze\u2013wound interface leading to open rebleeding wounds upon material removal. Among the EPs, wound closure and clot\u2010mediated tissue adhesion are influenced by the chemical functionality of polyesters with \u2013COOH EPs performing better than \u2013NH\n                    <jats:sub>2<\/jats:sub>\n                    EPs.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503397","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T10:16:52Z","timestamp":1766744212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nanofibrous Electrospun Patches Fabricated from Biodegradable Polyesters Provide Effective Hemorrhage Control"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5341-7657","authenticated-orcid":false,"given":"Prathamesh","family":"Mane","sequence":"first","affiliation":[{"name":"Department of Bioengineering Interdisciplinary Science and Engineering Center Northeastern University 805 Columbus Ave Boston MA 02120 USA"},{"name":"School of Polymer Science and Polymer Engineering Goodyear Polymer Center University of Akron 170 University Ave Akron OH 44325 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-1818","authenticated-orcid":false,"given":"Avanti","family":"Pandit","sequence":"additional","affiliation":[{"name":"School of Polymer Science and Polymer Engineering Goodyear Polymer Center University of Akron 170 University Ave Akron OH 44325 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9906-1556","authenticated-orcid":false,"given":"Mahdi","family":"Zafari","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Interdisciplinary Science and Engineering Center Northeastern University 805 Columbus Ave Boston MA 02120 USA"},{"name":"School of Polymer Science and Polymer Engineering Goodyear Polymer Center University of Akron 170 University Ave Akron OH 44325 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6254-6669","authenticated-orcid":false,"given":"Joshua","family":"Menefee","sequence":"additional","affiliation":[{"name":"School of Polymer Science and Polymer Engineering Goodyear Polymer Center University of Akron 170 University Ave Akron OH 44325 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1854-9523","authenticated-orcid":false,"given":"Christopher W.","family":"Barney","sequence":"additional","affiliation":[{"name":"School of Polymer Science and Polymer Engineering Goodyear Polymer Center University of Akron 170 University Ave Akron OH 44325 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Olson Research Center University of Akron 260 S Forge St Akron OH 44325 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7781-3817","authenticated-orcid":false,"given":"Abraham","family":"Joy","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Interdisciplinary Science and Engineering Center Northeastern University 805 Columbus Ave Boston MA 02120 USA"},{"name":"School of Polymer Science and Polymer Engineering Goodyear Polymer Center University of Akron 170 University Ave Akron OH 44325 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"S4","volume":"71","author":"Eastridge B. 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