{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T19:19:09Z","timestamp":1775848749223,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2400703"],"award-info":[{"award-number":["2021YFC2400703"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer immunotherapies, such as programmed cell death protein 1 (PD\u20101) inhibitors, cancer vaccines, and chimeric antigen receptor T cells (CAR\u2010T cells), have become first\u2010line treatments for multiple tumors by eliciting antitumor immunity. However, their limited efficacy in immunosuppressive tumors, particularly Head and Neck Squamous Cell Carcinoma (HNSCC), underscores the urgent need for versatile therapeutics. Hereinto, we develop an injectable hydrogel incorporating Mg microparticles and Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    magnetic nanoparticles (Mg\/Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Gel) to enhance antitumor immunotherapy, achieving potent vaccine\u2010like tumor suppression against both distant and newly emerging tumors. Under an alternating magnetic field, Mg\/Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Gel induces HNSCC cell death via magnetic hyperthermia, while simultaneously triggering mitochondrial dysfunction and disrupting redox homeostasis, resulting in a 72% apoptosis rate. Meanwhile, the released corrosion products effectively neutralize the intracellular acidic environment, further enhancing the efficacy of systemic immunotherapy. Mechanistic studies induce Mg\/Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Gel immunogenic cell death via Ltf regulation, facilitating effective eradication of both primary and distant lesions. Moreover, vaccination with Mg\/Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Gel\u2010killed tumor cells and adoptive CD3\n                    <jats:sup>+<\/jats:sup>\n                    T cell transfer confer robust antitumor immunity, achieving 80% tumor growth suppression in immunodeficient models and surpassing typical clinical outcomes. Overall, our study highlights the potential of this metal\u2010based hydrogel as a universal platform to enhance antitumor efficacy through a synergistic immunotherapeutic strategy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503398","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T15:18:58Z","timestamp":1767799138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnesium\u2010Enhanced Magnetic Hyperthermia for Triggering Vaccine\u2010Like Antitumor Immunotherapy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-107X","authenticated-orcid":false,"given":"Zhenyuan","family":"Han","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery National Clinical Research Center for Oral Diseases National Center for Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics National Center for Stomatology National Clinical Research Center for Oral Diseases Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery National Clinical Research Center for Oral Diseases National Center for Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of Stomatology  Beijing 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