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Microbial metabolism of tryptophan yields indole\u20103\u2010propionic acid (IPA), an emerging biomarker for gut inflammation. Current IPA detection relies on expensive, time\u2010consuming mass spectrometry. To address this limitation, a fluorescent nanosensor system is presented that uniquely features two optical modalities: one utilizing near\u2010infrared (NIR) emission of a central single\u2010walled carbon nanotube (SWNT), and a separate, visible emission from the corona phase polymer, a cationic conjugated polyelectrolyte (CP3). Selective IPA molecular recognition occurs at the latter, but the binding is optically reported via quenching in both the visible and NIR emission channels. The two modalities provide complementary advantages: CP3\u2010SWNTs\u2019 NIR channel enables detection in strongly scattering tissue environments due to reduced Rayleigh scattering at longer wavelengths. 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