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Supplementation of exogenous insulin can't protect remaining \u03b2\u2010cells or address the root autoimmune cause. The emerging therapeutic strategies focus on immunomodulatory approaches, targeting the activation of the programmed death 1\/programmed death ligand 1 (PD\u20101\/PD\u2010L1) pathway could attenuate T cell\u2010mediated \u03b2\u2010cell destruction, thereby alleviating inflammation in early\u2010stage T1DM. However, nonselective PD\u20101\/PD\u2010L1 blockade can cause toxicity. Herein, exosomes from PD\u2010L1\n                    <jats:sup>high<\/jats:sup>\n                    MCF\u20107 cells are utilized, modified with monocyte\u2010targeting IgG, and have their contents removed via electroporation to eliminate tumorigenicity. Monocytes have the characteristic of targeting inflammatory sites. rExo\u2010IgG is stably anchored to the monocytes\u2019 membrane through IgG and transported as a backpack of monocytes to the inflammatory sites (pancreas and wounds). In the pancreatic tissue, rExo\u2010IgG through PD\u20101\/PD\u2010L1 pathway, inhibiting their activation and protecting \u03b2\u2010cells. At the site of tissue injury, rExo\u2010IgG repolarizes macrophages from pro\u2010inflammatory M1 to anti\u2010inflammatory M2. It also promotes fibroblast proliferation and migration, enhancing tissue regeneration. This dual\u2010targeting exosome platform not only exhibits therapeutic efficacy against early\u2010stage T1DM but also offers a novel strategy for the treatment of diabetic wound healing disorders.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503453","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:56:56Z","timestamp":1761022616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Monocyte Backpack Delivery of Engineered MCF\u20107 Exosomes for the Treatment of Early Stage Type 1 Diabetes"],"prefix":"10.1002","volume":"15","author":[{"given":"Ziyang","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Science Key Laboratory of Pharmaceutical Quality Control of Hebei Province Hebei University  Baoding 071002 P. R. China"},{"name":"College of Chemistry &amp; Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding 071002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichuan","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding 071002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxin","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Key Laboratory of Pharmaceutical Quality Control of Hebei Province Hebei University  Baoding 071002 P. R. China"},{"name":"College of Chemistry &amp; Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding 071002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding 071002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding 071002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding 071002 P. R. China"},{"name":"Affiliated Hospital of Hebei University Baoding 071000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Hebei University Baoding 071000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding 071002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding 071002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-0864","authenticated-orcid":false,"given":"Zhenhua","family":"Li","sequence":"additional","affiliation":[{"name":"The Tenth Affiliated Hospital Southern Medical University (Dongguan People's Hospital)  Dongguan 523059 P. R. 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