{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:22:50Z","timestamp":1790742170494,"version":"4.1.0"},"reference-count":154,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL105373"],"award-info":[{"award-number":["T32HL105373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007444"],"award-info":[{"award-number":["T32HL007444"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL160507"],"award-info":[{"award-number":["T32HL160507"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>To mitigate the pathological effects of myocardial infarction, we developed and investigated a pro\u2010reparative decellularized extracellular matrix (ECM) biomaterial, an intravascularly infusible ECM (iECM). However, the cellular and molecular mechanisms by which iECM mediates repair are unknown because investigations have relied on bulk techniques. Here, we leverage single\u2010nucleus RNA sequencing (snRNAseq) to measure pro\u2010repair responses in various cell types across acute timepoints (1, 3, and 7 days post infusion). In iECM, we found pro\u2010reparative macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis. These findings are validated through spatial transcriptomics. Thus, we define the pro\u2010reparative nature of the decellularized ECM biomaterial on cardiac cell types and elucidate previously undiscovered therapeutic pathways, further demonstrating the potential of iECM as an MI therapy, as well as display the wealth of data generated from next\u2010generation sequencing.<\/jats:p>","DOI":"10.1002\/adhm.202503469","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:57:11Z","timestamp":1766123831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Infusible Extracellular Matrix Biomaterial Enhances Cell\u2010Specific Pro\u2010Repair Responses Following Acute Myocardial Infarction"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1022-8175","authenticated-orcid":false,"given":"Joshua M.","family":"Mesfin","sequence":"first","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Chen","sequence":"additional","affiliation":[{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"},{"name":"Program in Materials Science and Engineering University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1042-5627","authenticated-orcid":false,"given":"Quincy P.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-2371","authenticated-orcid":false,"given":"Maria L.","family":"Karkanitsa","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Yu","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Division of Cardiology Department of Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6017-4035","authenticated-orcid":false,"given":"Van K.","family":"Ninh","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Division of Cardiology Department of Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Gardner","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse G.","family":"Wong","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriya N.","family":"Paleti","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8986-5201","authenticated-orcid":false,"given":"Benjamin D.","family":"Bridgelal","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5353-4614","authenticated-orcid":false,"given":"Kate E.","family":"Reimold","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selena","family":"Cao","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Uhre","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin G.","family":"Luo","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Fu","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Division of Cardiology Department of Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1472-2189","authenticated-orcid":false,"given":"Kevin R.","family":"King","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Division of Cardiology Department of Medicine University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-898X","authenticated-orcid":false,"given":"Karen L.","family":"Christman","sequence":"additional","affiliation":[{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA"},{"name":"Program in Materials Science and Engineering University of California San Diego La Jolla CA USA"},{"name":"Sanford Stem Cell Institute University of California San Diego La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Comprehensive Physiology","author":"Frangogiannis N. G.","year":"2015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008\u20106363(01)00434\u20105"},{"key":"e_1_2_11_4_1","first-page":"151","article-title":"E. on Behalf of the American Heart Association Council on, C. Prevention Statistics, C. Stroke Statistics","author":"Martin S. S.","year":"2025","journal-title":"Circulation"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300603"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070885"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.5.480"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.70080"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2013.67"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.6093"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44161\u2010022\u201000160\u20103"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170689"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.06.045"},{"key":"e_1_2_11_14_1","first-page":"5","article-title":"Safety and Efficacy of an Injectable Extracellular Matrix Hydrogel for Treating Myocardial Infarction","author":"Seif\u2010Naraghi S. B.","year":"2013","journal-title":"Science Translational Medicine"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.035"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2013.739156"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010024\u201000213\u20101"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007806\u20101"},{"key":"e_1_2_11_19_1","article-title":"Single\u2010Cell Dissection of the Immune Response after Acute Myocardial Infarction","volume":"17","author":"Blokland I. V.","year":"2024","journal-title":"Circulation: Genomic and Precision Medicine"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010021\u201000770\u20105"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041608\u20109"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celbio.2025.100099"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122685"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201065351\u20105"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010022\u201000964\u20105"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300782"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2797-4"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44161\u2010022\u201000028\u20106"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11991"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.633609"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.10.030"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05\u20101528"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201002\u2010410076"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010022\u201001180\u20105"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201004754\u20104"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000254788.47304.6e"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17314"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20101979\u20104"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH\u2010242254"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006377"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16509"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5261729"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201085408\u2010x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109\u2010022\u201002240\u20100"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.02.033"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010021\u201001103\u20103"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.07.010"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.174995"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030562"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.27599"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.10.015"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883\u2010024\u201001196\u20105"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.320270"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.3.402"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5143"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010023\u201003267\u2010x"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.910703"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.630471"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145210"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456\u2010013\u20109370\u20109"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.07.019"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aal2987"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201002019\u20104"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512318"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010023\u201000913\u2010y"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14204"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19\u20100448"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010023\u201005095\u2010x"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189829"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031811"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2024\u20100031ED"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.02.064"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09045"},{"key":"e_1_2_11_74_1","first-page":"1977","article-title":"COL6A1 Knockdown Suppresses Cell Proliferation and Migration in Human Aortic Vascular Smooth Muscle Cells","volume":"18","author":"Chen Z.","year":"2019","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu226"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007038"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.06.065"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.10.020"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.03.001"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj5830"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41435\u2010024\u201000298\u2010z"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2625"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9120409"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.33963\/KP.a2021.0042"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.63642"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2024.01.006"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1515\/pteridines\u20102020\u20100031"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03206-4"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.04.011"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14050345"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1499065"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.01.008"},{"key":"e_1_2_11_93_1","first-page":"367","article-title":"Integrated Bioinformatics Analysis of Retinal Ischemia\/Reperfusion Injury in Rats with Potential Key Genes","volume":"25","author":"Qing K.\u2010X.","year":"2024","journal-title":"BMC Genomics [Electronic Resource]"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109002"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01840-1"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.802066"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052715"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2017.06.006"},{"key":"e_1_2_11_99_1","first-page":"1","article-title":"Cardiac Macrophages Promote Polarization of Macrophages toward M2 Phenotype to Improve Myocardial Remodeling via NGAL after Myocardial Infarction","author":"Shen D.","year":"2025","journal-title":"Cell Biochemistry and Biophysics"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311327"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0686-x"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16757"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4375127"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755\u20108794\u20104\u201083"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.34801"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.10.380"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34295"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.035"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010018\u20100077\u2010x"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70193"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201021202\u20107"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00496.2019"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557\u2010018\u20106820\u2010z"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2021.1982158"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010022\u201008778\u20100"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1879"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.04.028"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.136852"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201027622\u20109"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.28"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012509"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24498"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5187304"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1199"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.039530"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001444\u20101"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319425"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126555"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac039"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8183420"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.045377"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607382103"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11558"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001532"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010024\u201001982\u2010y"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz\u20102018\u20100195"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142\u2010011\u20100256\u2010x"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.01.050"},{"key":"e_1_2_11_139_1","article-title":"Integrin \u03b21 Increases Stem Cell Survival and Cardiac Function after Myocardial Infarction","volume":"8","author":"Li L.","year":"2017","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.77694"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010021\u201000776\u20109"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402507200"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.45303"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1997.0660"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009119117"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.12.081"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20101716.2005.01503.x"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495\u2010025\u201002078\u20100"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3925"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.06.030"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2014.08.005"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4428"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaz1974"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14111462"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm560"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202503469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202503469","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202503469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:52:29Z","timestamp":1784296349000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202503469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":154,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/adhm.202503469"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202503469","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.11.08.687255","asserted-by":"object"}]},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"2025-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03469"}}