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Given the limitations of traditional dressings, static drug release mechanisms, and singular antibacterial action, along with the issue of drug resistance exacerbated by the overuse of antibiotics, a dual dynamic cross\u2010linked network composite hydrogel (CSGA\u2010Cip) is developed to overcome these challenges. The hydrogel forms a dynamic adaptive network through Schiff base bonds and Ag\u2500S coordination bonds, endowing it with injectable and self\u2010healing properties. Notably, a staged low\u2010frequency ultrasound intervention strategy is employed to achieve a cascade treatment of antibacterial ordered regeneration. During acute infection (0\u20133 days), continuous low\u2010frequency ultrasound facilitates the rapid release of silver ions (Ag\u207a) and ciprofloxacin (Cip), synergizing with glutathione (GSH) to establish multiple antibacterial barriers. In the repair stage (3\u20139 days), pulsed low\u2010frequency ultrasound activated cell migration and angiogenesis signaling pathways to guide tissue regeneration. Animal studies have confirmed that this strategy significantly enhances infectious wound healing, promotes orderly collagen deposition, and stimulates angiogenesis, thereby providing an innovative paradigm for the treatment of infectious wounds.<\/jats:p>","DOI":"10.1002\/adhm.202503471","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:57:56Z","timestamp":1761285476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Staged Low\u2010Frequency Ultrasound Synergized with Composite Hydrogel to Achieve \u201cRapid Antimicrobial\u2010Ordered Regeneration\u201d of Infected Wounds"],"prefix":"10.1002","volume":"15","author":[{"given":"Yixin","family":"Li","sequence":"first","affiliation":[{"name":"College of Biomedical Engineering Chongqing Medical University  Chongqing 400016 P. R. 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