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Our study develops a novel placenta\u2010targeted nanodelivery system, termed HN@DC NPs, which is formulated with DSPC (1,2\u2010distearoyl\u2010sn\u2010glycero\u20103\u2010phosphocholine), DSPE\u2010PEG2000 (1,2\u2010distearoyl\u2010sn\u2010glycero\u20103\u2010phosphoethanolamine\u2010N\u2010[methoxy (polyethylene glycol)\u20102000]), and DSPE\u2010PEG\u2010CSA (DSPE\u2010PEG2000\u2010chondroitine sulfate A). This system is designed to co\u2010deliver key inflammatory mediators\u2014nucleotide\u2010binding oligomerization domain, leucine\u2010rich repeat, and pyrin domain\u2010containing 3 (NLRP3) agonist nigericin and high mobility group box\u20101 protein (HMGB1), which are identified from pregnant women with atonic PPH to establish a pathophysiologically relevant animal model. The HN@DC NPs achieve precise enrichment in placental trophoblasts and effective diffusion into decidua with good short\u2010term biocompatibility. The pregnant rats model constructed by HN@DC NPs shows prolonged labor duration and weakened uterine smooth muscle contractility with the activation of inflammatory markers in the placental decidua. The new insight into a reproducible construction strategy of the atonic PPH animal model in this study promotes the mechanism research and clinical therapeutic development of atonic PPH.<\/jats:p>","DOI":"10.1002\/adhm.202503475","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:42:44Z","timestamp":1763966564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiangxue","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"National Center for Healthcare Quality Management in Obstetrics  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