{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:06:33Z","timestamp":1788314793454,"version":"build-2803163510"},"reference-count":76,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["202108390033"],"award-info":[{"award-number":["202108390033"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atrial fibrillation (AF) is a common arrhythmia that can cause serious symptoms and affect the quality of life of patients. Therefore, the treatment of AF has always faced challenges in the medical field. Here, Zn@Mg@MSNs@PEG nanosphere\u2010based nanomachines with a unique composite structure in which Zn and Mg are deposited on the surface of mesoporous silica nanoparticle (MSNs) nanospheres, followed by polyethylene glycol (PEG) modification, display excellent acid\u2010responsive properties due to their unique ion sputtering structure. The nanomaterials show autonomous mobility in PBS with acid input, without the use of energetic toxic fuels. This active release of Zn\n                    <jats:sup>2+<\/jats:sup>\n                    \/Mg\n                    <jats:sup>2+<\/jats:sup>\n                    \/H\n                    <jats:sub>2<\/jats:sub>\n                    improves the intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/Na\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    \/Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    ratio via nanomachines. The intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/Na\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    \/Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    gradients are the key to AF electrophysiology. Electrophysiology amelioration combined with oxidative stress and inflammatory mediator inhibition is found to mediate AF following Zn@Mg@MSNs@PEG nanomachine invasion. The designed star arrow\u2010separated nanomachine system, activated by acidic conditions to enhance mobility and enable the targeted release of Zn\n                    <jats:sup>2<\/jats:sup>\n                    \u207a, Mg\n                    <jats:sup>2<\/jats:sup>\n                    \u207a, and H\n                    <jats:sub>2<\/jats:sub>\n                    , effectively inhibits cardiac remodeling associated with AF by precisely targeting both structural and electrical abnormalities, achieving therapeutic effects without causing additional damage.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503478","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:14:32Z","timestamp":1759958072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Precisely Targeting Cardiac Remodeling Nanomachine for Restarting Healthy Heartbeat"],"prefix":"10.1002","volume":"15","author":[{"given":"Weixin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Binzhou Medical University  Yantai 264003 P. R. China"},{"name":"Chinese Acad Sci Yantai Inst Coastal Zone Res  Yantai Shandong 264003 P. R. China"},{"name":"Qingdao Academy of Chinese Medicine Sciences Shandong University of Traditional Chinese Medicine  Qingdao 266112 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Binzhou Medical University  Yantai 264003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Binzhou Medical University  Yantai 264003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Binzhou Medical University  Yantai 264003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Binzhou Medical University  Yantai 264003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Dai","sequence":"additional","affiliation":[{"name":"Clinical Medical Research Center Xinqiao Hospital Army Military Medical University  Chongqing 400038 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University  Shenyang 110122 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Testing Technology for Agro\u2010Products Sichuan Academy of Agricultural Sciences  Chengdu 637000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanle","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Guangzhou Medical University  Guangzhou 511436 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[{"name":"UCL Division of Medicine University College London  Gower St London WC1E 6BT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-9778","authenticated-orcid":false,"given":"Fei","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Binzhou Medical University  Yantai 264003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Flexible Electronics, Institute of Flexible Electronics (IFE) Northwestern Polytchnical University  Xi'an 710072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.03.379"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035202"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.11.043"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.10.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0320"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520936415"},{"key":"e_1_2_9_7_1","first-page":"108","volume":"3","author":"Baker W. L.","year":"2017","journal-title":"Eur. Heart J. Cardiovasc. Pharmacother."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01679-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-22-534"},{"key":"e_1_2_9_10_1","volume":"2022","author":"Liu Y.","year":"2022","journal-title":"Research"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.2014382"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.906350"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR07456H"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303219"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1360\/TB-2023-0802"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c10043"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7TB00328E"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR00062A"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR04808J"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202013689"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202000512"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b13-00661"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-017-0192-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00324-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14678"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000058462.23347.93"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.10.005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281707"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.64.083101.145105"},{"key":"e_1_2_9_30_1","first-page":"168","volume":"28","author":"Fu Y.","year":"2012","journal-title":"J. Clin. Cardiol."},{"key":"e_1_2_9_31_1","first-page":"1","volume":"162","author":"Grunnet M.","year":"2012","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.082511"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145659.80212.6A"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/415219a"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002183"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157976"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.04.050"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.02.009"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-009-0452-6"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2010_03_222"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300245"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11302"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02783179"},{"key":"e_1_2_9_44_1","first-page":"130","volume":"39","author":"G\u00fclker H.","year":"1989","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14211"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.06.055"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.153055"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21220"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.08.231"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00227-x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708018114"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-023-01814-8"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.05.003"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11864"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020911-153308"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.01.024"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acmx.2013.12.008"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006611"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.001973"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12395"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000343"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw002"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv231"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.05.002"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv153"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2016.1159300"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2019.183148"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2015.04.007"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0303-y"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.757955"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-019-06925-6"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002333"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa010"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu005"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35212"},{"key":"e_1_2_9_76_1","first-page":"224","volume":"36","author":"Li Q.","year":"2024","journal-title":"Chinese Heart J."}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202503478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202503478","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202503478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:24:46Z","timestamp":1768897486000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202503478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/adhm.202503478"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202503478","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"2025-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03478"}}