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A modular, protein\u2010only nanoscaffold based on recombinant ring\u2010like particles (RLPs) derived from a viral nucleoprotein (\n                    <jats:italic>NP<\/jats:italic>\n                    ), engineered is presented to display high\u2010affinity, de novo\u2010designed minibinders (LCB1 and LCB3) targeting SARS\u2010CoV\u20102 Spike (\n                    <jats:italic>S<\/jats:italic>\n                    )protein. These binders are site\u2010specifically fused to either the N\u2010 or C\u2010termini, or both ends of\n                    <jats:italic>NP<\/jats:italic>\n                    to ensure functional orientation and dense, multivalent display. The resulting constructs self\u2010assemble into stable, biocompatible, and homogeneous nanoparticles that potently inhibit\n                    <jats:italic>S<\/jats:italic>\n                    \u2013angiotensin\u2010converting enzyme 2 receptor (ACE2r)\u00a0interactions, neutralizing both pseudotyped viral\u2010like particles and authentic SARS\u2010CoV\u20102, including Omicron BA.5. The dual\u2010display nanoparticle (RLP\u20101,3), presenting 10 LCB1 and 10 LCB3 domains, exhibit synergistic binding activity, with fM Half Maximal Inhibitory Concentration(IC\n                    <jats:sub>50<\/jats:sub>\n                    ) values, outperforming benchmark monoclonal antibodies and clinically approved hyperimmune therapies. Additionally, RLP\u20101,3 is adapted for diagnostics in an ELISA platform, achieving a Spike protein detection limit of 9\u00a0ng\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , surpassing commercial assays. This work demonstrates how the convergence of AI\u2010guided binder design and structure\u2010based nanoscaffolding enables next\u2010generation multifunctional bio\u2010nanomaterials. The RLP\u2010minibinder system offers a generalizable, scalable, and cost\u2010efficient plug\u2010and\u2010(dis)play solution with integrated therapeutic and diagnostic capabilities, positioning it as a flexible alternative to ABTs for pandemic preparedness.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503487","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T04:16:57Z","timestamp":1759724217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multivalent Protein Nanorings for Broad and Potent SARS\u2010CoV\u20102 Neutralization"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7889-6105","authenticated-orcid":false,"given":"Molood","family":"Behbahanipour","sequence":"first","affiliation":[{"name":"Institut de Biotecnologia i de Biomedicina (IBB) and Departament de Bioqu\u00edmica i Biologia Molecular Universitat Aut\u00f2noma de 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