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This study develops a carrier\u2010free Cu\u2010SCU hydrogel via self\u2010assembly of scutellarin (SCU) and copper ions (Cu\n                    <jats:sup>2<\/jats:sup>\n                    \u207a), without polymers or excipients. Spectroscopic analyses and molecular dynamics simulation confirm Cu\u2010SCU coordination, yielding an injectable hydrogel with mechanical integrity. In vitro, Cu\u2010SCU demonstrates excellent biocompatibility, potent ROS scavenging, and immunomodulation by polarizing macrophages to the reparative M2 phenotype. It also exhibits strong hemostatic activity, promoting RBC\/platelet aggregation and accelerating coagulation in vitro and in vivo (liver hemorrhage and tail\u2010amputation models). In diabetic full\u2010thickness wounds, Cu\u2010SCU significantly accelerates healing, enhances re\u2010epithelialization, collagen deposition, and vascular maturation. Analyses reveal reduced neutrophilic infiltration, diminished pro\u2010inflammatory cytokines, and sustained M2 macrophage presence. Proteomic analysis and Western blot validation results demonstrated that it promotes angiogenesis by regulating the MAPK, cGMP\u2010PKG, VEGF, and HIF\u20101 signaling pathways, as well as upregulating the expression of key pathway proteins including HIF\u20101\u03b1, CDC42, and HK2. Cu\u2010SCU hydrogel promotes healing through multifaceted mechanisms: redox regulation, immune modulation, and pro\u2010angiogenic activation. This simple, biocompatible, and efficacious platform offers a promising alternative to carrier\u2010based systems for chronic wound therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503562","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:07:26Z","timestamp":1768381646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Multifunctional Copper Ion\u2010Mediated Carrier\u2010Free Scutellarin Hydrogel for Diabetic Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Fei","family":"Xia","sequence":"first","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao\u2010di Herbs Artemisinin Research Center, and Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences  Beijing 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