{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:22:08Z","timestamp":1785766928331,"version":"3.56.0"},"reference-count":121,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2017869"],"award-info":[{"award-number":["2017869"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS125016"],"award-info":[{"award-number":["R01NS125016"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R21EB033495"],"award-info":[{"award-number":["R21EB033495"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Most brain organoids derived from human induced pluripotent stem cells (iPSCs) lack microglia and thus immune function. Microglia\u2010like cells (MGCs) can be differentiated from iPSCs, while the characteristics of isogenic MGC\u2010containing brain organoids in modeling neurodegeneration and cell\u2010cell communications have not been well investigated. In this study, iPSC\u2010derived MGCs are co\u2010cultured with isogenic forebrain cortical organoids (iFCo), which are stimulated with extracellular vesicles (EVs) of brain organoids differentiated from Alzheimer's disease (AD) patient\u2010derived iPSCs (\n                    <jats:italic>APOE<\/jats:italic>\n                    \u03b54\/\u03b54 and presenilin 1). The AD EV\u2010stimulated co\u2010culture organoids are treated with EVs from healthy MGCs or co\u2010culture. Differential responses of the co\u2010cultured organoids and the MGCs to AD EVs are demonstrated. The co\u2010cultured organoids mitigated pro\u2010inflammatory gene expressions. EVs from healthy MGCs or co\u2010culture reduced the expression of\n                    <jats:italic>IL\u201012\u03b2<\/jats:italic>\n                    ,\n                    <jats:italic>iNOS<\/jats:italic>\n                    ,\n                    <jats:italic>TREM2<\/jats:italic>\n                    , and\n                    <jats:italic>CASS4<\/jats:italic>\n                    , which are associated with neural inflammation and degeneration, as well as showed regulation on genes involved in microglial activation and carbon metabolism. AD EV cargo analysis by proteomics and microRNA\u2010sequencing revealed APOE and APP proteins and microRNAs regulated pathways such as mitophagy. This study paves the way for understanding the role of microglia and brain organoids in modeling neural degeneration and the development of EV\u2010based cell\u2010free therapeutics for AD treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503579","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T06:57:31Z","timestamp":1766041051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immuno\u2010Regulation of Brain Region\u2010Specific Organoids Containing Isogenic Microglia\u2010Like Cells"],"prefix":"10.1002","volume":"15","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomedical Engineering FAMU\u2010FSU College of Engineering Florida State University  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justice","family":"Ene","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomedical Engineering FAMU\u2010FSU College of Engineering Florida State University  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falak","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomedical Engineering FAMU\u2010FSU College of Engineering Florida State University  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomedical Engineering FAMU\u2010FSU College of Engineering Florida State University  Tallahassee Florida USA"},{"name":"Department of Biomedical Sciences College of Medicine Florida State University  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u2010Caroline","family":"Raulin","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Medicine Florida State University  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueju","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering University of Connecticut  Storrs Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Kanekiyo","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-8519","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomedical Engineering FAMU\u2010FSU College of Engineering Florida State University  Tallahassee Florida USA"},{"name":"Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12517"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3368"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3415"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0085-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2020.0135"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087660"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47444-6"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06713-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4238"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.01.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110006"},{"key":"e_1_2_11_13_1","article-title":"Microglia Gravitate Toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2","author":"Park J. C.","year":"2024","journal-title":"Advance Science"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.01.008"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0616-08.2008"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90606"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3318"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010124"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06684-2"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4189"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.03.042"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.04.023"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02766"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72214-0"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.08.015"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01892-1"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12235"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12472"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jex2.133"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00410-w"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304025"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.81860"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jex2.70002"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c22692"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.566530"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.12.020"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00440-9"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac083"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.08.041"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2017.0153"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42439-9"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19264-0"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2017.0423"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2016.0400"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47444-6"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16970-1"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2022.108711"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.07.004"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2012.0690"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.11.016"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.09.020"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2019.0349"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay4361"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2020.0243"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8090993"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01286"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7253-1_25"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2018.05.022"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0291-z"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.08.008"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-022-00279-0"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-019-01775-3"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1156-z"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-014-0101-6"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa209"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.856376"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184467"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4338"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.12.018"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0072-1"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710311114"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0216-6"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.803"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201642738"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt478"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2018.1025"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv371"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.05.006"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-02004-0"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01258-1"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3736"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe4499"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41983-021-00420-2"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601781"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0905-17.2017"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9357"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00761-1"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4124-10.2010"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00176"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11111735"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3302"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12839"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06249-2"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102810"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12900-018-0099-y"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.14723"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.06.014"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crphar.2022.100149"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23045"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0536-x"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.749587"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.4.10.1265"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155582"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1811411115"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-024-00454-5"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-024-00789-7"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3131-15.2016"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.662242"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23356"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-025-00825-0"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00435-y"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102846"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncoscience.64"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170278"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000823R"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.09.004"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.969547"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-00988-2"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.01.002"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.07.754"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190074"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01631-6"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202503579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202503579","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202503579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:14:22Z","timestamp":1785453262000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202503579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":121,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/adhm.202503579"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202503579","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]},"assertion":[{"value":"2025-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03579"}}