{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T19:19:05Z","timestamp":1775848745946,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2025SF\u2010YBXM\u2010245"],"award-info":[{"award-number":["2025SF\u2010YBXM\u2010245"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dental caries poses significant therapeutic challenges due to resilient biofilms and uncontrolled demineralization. To address these challenges, by leveraging the broad antimicrobial activity and strong phosphate\u2010binding capability of arginine peptides, we developed dental adhesive nanonets to effectively capture and kill\n                    <jats:italic>S. mutans<\/jats:italic>\n                    strain for caries management. FmocFFRRR was selected from a two\u2010round structural screening, and was co\u2010assembled with sodium monofluorophosphate (MFP) to construct multifunctional nanonets (\n                    <jats:bold>F@MFP<\/jats:bold>\n                    ). Specifically,\n                    <jats:bold>F@MFP<\/jats:bold>\n                    nanonets adhere robustly to tooth enamel, capture\n                    <jats:italic>S. mutans<\/jats:italic>\n                    via electrostatic interactions, and kill\n                    <jats:italic>S. mutans<\/jats:italic>\n                    by disrupting bacterial membrane integrity, inducing oxidative stress, and suppressing metabolic activities.\n                    <jats:bold>F@MFP<\/jats:bold>\n                    nanonets not only inhibit biofilm formation but also effectively dismantle mature biofilms by downregulating biofilm\u2010associated virulence genes. Furthermore,\n                    <jats:bold>F@MFP<\/jats:bold>\n                    nanonets also serve as a fluoride reservoir to inhibit demineralization and promote enamel remineralization. In vivo experiments reveal that\n                    <jats:bold>F@MFP<\/jats:bold>\n                    exhibits superior caries\u2010inhibiting efficacy. This multifunctional platform integrates dental adhesion, a capture\u2010and\u2010kill antibacterial mechanism, anti\u2010biofilm properties, and enamel repair capacity, offering a novel paradigm for targeted caries therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503597","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:26:36Z","timestamp":1768976796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dental Adhesive Peptides Nanonets as Multifunctional Therapy for Caries"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6411-3766","authenticated-orcid":false,"given":"Liang","family":"Shao","sequence":"first","affiliation":[{"name":"Laboratory of Biotherapy National Key Laboratory of Biotherapy Cancer Center West China Hospital Sichuan University  Chengdu Sichuan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biophysics School of Basic Medical Sciences Health Science Centre Xi'an Jiaotong University  Xi'an Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biophysics School of Basic Medical Sciences Health Science Centre Xi'an Jiaotong University  Xi'an Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Biophysics School of Basic Medical Sciences Health Science Centre Xi'an Jiaotong University  Xi'an Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiting","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Biophysics School of Basic Medical Sciences Health Science Centre Xi'an Jiaotong University  Xi'an Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biophysics School of Basic Medical Sciences Health Science Centre Xi'an Jiaotong University  Xi'an Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biophysics School of Basic Medical Sciences Health Science Centre Xi'an Jiaotong University  Xi'an Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biophysics School of Basic Medical Sciences Health Science Centre Xi'an Jiaotong University  Xi'an Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biophysics School of Basic Medical Sciences Health Science Centre Xi'an Jiaotong University  Xi'an Shaanxi P. R. 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-2887","authenticated-orcid":false,"given":"Guanying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biophysics School of Basic Medical Sciences Health Science Centre Xi'an Jiaotong University  Xi'an Shaanxi P. R. China"},{"name":"Department of Orthopedic Surgery The Second Affiliated Hospital of Xi'an Jiaotong University  Shaanxi P. R. 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